Tian Jing, Wu Zhongyuan, Wang Yuan, Han Chunhua, Zhou Zixuan, Guo Di, Lin Yifan, Ye Zhou, Fu Jing
Department of Prosthodontics, The Affiliated Hospital of Qingdao University, Qingdao, China; School of Stomatology, Qingdao University, Qingdao, China.
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Oral Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
J Mech Behav Biomed Mater. 2023 May;141:105783. doi: 10.1016/j.jmbbm.2023.105783. Epub 2023 Mar 15.
The inherent characteristics of resin composite can lead to micro-leakage after polymerization shrinkage. The bacteria invasion through edge micro-leakage and attachment onto the material surface can cause secondary caries, reducing the service life of resin composites. In this study, magnesium oxide nanoparticles (nMgO) as an inorganic antimicrobial agent and bioactive glass (BAG) as a remineralization agent were simultaneously incorporated into the resin composite. With the addition of both nMgO and BAG, the resin composite showed an excellent antimicrobial effect compared to the resin composite with nMgO or BAG only. The remineralization capacity of demineralized dentin increased with the increasing content of BAG. Vickers hardness, compressive strength, and flexural strength of the resin composite with nMgO-BAG were not significantly affected compared to the ones with the same total filler amount but with BAG only. The depth of cure and water sorption values of the resin composite showed an increasing trend with the increasing total amount of nMgO and BAG fillers. This developed multifunctional resin composite is expected to reduce bacterial invasion and promote remineralization of early caries damage.
树脂复合材料的固有特性会导致聚合收缩后出现微渗漏。细菌通过边缘微渗漏侵入并附着在材料表面会引发继发龋，从而缩短树脂复合材料的使用寿命。在本研究中，氧化镁纳米颗粒（nMgO）作为无机抗菌剂，生物活性玻璃（BAG）作为再矿化剂，被同时加入到树脂复合材料中。与仅添加nMgO或BAG的树脂复合材料相比，同时添加nMgO和BAG的树脂复合材料表现出优异的抗菌效果。脱矿牙本质的再矿化能力随BAG含量的增加而增强。与仅含相同总量填料但仅含BAG的树脂复合材料相比，含nMgO - BAG的树脂复合材料的维氏硬度、抗压强度和抗弯强度没有受到显著影响。树脂复合材料的固化深度和吸水率值随nMgO和BAG填料总量的增加呈上升趋势。这种研发出的多功能树脂复合材料有望减少细菌侵入，并促进早期龋损的再矿化。
