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用于靶向疫苗递送的脂质基胶体纳米颗粒。

Lipid-based colloidal nanoparticles for applications in targeted vaccine delivery.

作者信息

Khan Muhammad Saad, Baskoy Sila Appak, Yang Celina, Hong Joohye, Chae Jayoung, Ha Heejin, Lee Sungjun, Tanaka Masayoshi, Choi Yonghyun, Choi Jonghoon

机构信息

Department of Physics, Toronto Metropolitan University 350 Victoria Street Toronto M5B2K3 Canada.

Institute for Biomedical Engineering, Science and Technology (iBEST), St. Michael's Hospital 209 Victoria Street Toronto M5B1W8 Canada.

出版信息

Nanoscale Adv. 2023 Feb 17;5(7):1853-1869. doi: 10.1039/d2na00795a. eCollection 2023 Mar 28.

DOI:10.1039/d2na00795a
PMID:36998671
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10044484/
Abstract

Bioactive molecules and their effects have been influenced by their solubility and administration route. In many therapeutic reagents, the performance of therapeutics is dependent on physiological barriers in the human body and delivery efficacy. Therefore, an effective and stable therapeutic delivery promotes pharmaceutical advancement and suitable biological usage of drugs. In the biological and pharmacological industries, lipid nanoparticles (LNPs) have emerged as a potential carrier to deliver therapeutics. Since studies reported doxorubicin-loaded liposomes (Doxil®), LNPs have been applied to numerous clinical trials. Lipid-based nanoparticles, including liposomes, solid lipid nanoparticles (SLNs), and nanostructured lipid nanoparticles, have also been developed to deliver active ingredients in vaccines. In this review, we present the type of LNPs used to develop vaccines with attractive advantages. We then discuss messenger RNA (mRNA) delivery for the clinical application of mRNA therapeutic-loaded LNPs and recent research trend of LNP-based vaccine development.

摘要

生物活性分子及其作用受到其溶解度和给药途径的影响。在许多治疗试剂中，治疗效果取决于人体的生理屏障和递送效率。因此，有效且稳定的治疗递送促进了药物的进步以及药物的合理生物应用。在生物和制药行业中，脂质纳米颗粒（LNPs）已成为递送治疗药物的潜在载体。自从有研究报道了载有多柔比星的脂质体（Doxil®）以来，LNPs已被应用于众多临床试验。基于脂质的纳米颗粒，包括脂质体、固体脂质纳米颗粒（SLNs）和纳米结构脂质纳米颗粒，也已被开发用于递送疫苗中的活性成分。在本综述中，我们介绍了用于开发具有诱人优势的疫苗的LNPs类型。然后，我们讨论了用于负载mRNA治疗药物的LNPs临床应用的信使核糖核酸（mRNA）递送以及基于LNP的疫苗开发的最新研究趋势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9430/10044484/2993e17bbe62/d2na00795a-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9430/10044484/f91eb19708c9/d2na00795a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9430/10044484/69d44d9f1547/d2na00795a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9430/10044484/53bee1a1d376/d2na00795a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9430/10044484/13bd7536e182/d2na00795a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9430/10044484/9a535327ed40/d2na00795a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9430/10044484/2993e17bbe62/d2na00795a-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9430/10044484/f91eb19708c9/d2na00795a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9430/10044484/69d44d9f1547/d2na00795a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9430/10044484/53bee1a1d376/d2na00795a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9430/10044484/13bd7536e182/d2na00795a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9430/10044484/9a535327ed40/d2na00795a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9430/10044484/2993e17bbe62/d2na00795a-f6.jpg

相似文献

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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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本文引用的文献

[1]
Nanoparticles for vaccine and gene therapy: Overcoming the barriers to nucleic acid delivery.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2022-11

[2]
How to make plastic less of an environmental burden.

Nature. 2022-11

[3]
RTS,S/AS01 malaria vaccine (Mosquirix): a profile of its use.

Drugs Ther Perspect. 2022

[4]
Current Advances in Paper-Based Biosensor Technologies for Rapid COVID-19 Diagnosis.

Biochip J. 2022

[5]
Recent Developments in Innovative Magnetic Nanoparticles-Based Immunoassays: From Improvement of Conventional Immunoassays to Diagnosis of COVID-19.

Biochip J. 2022

[6]
Optimization of Lipid Nanoformulations for Effective mRNA Delivery.

Int J Nanomedicine. 2022

[7]
Low-dose self-amplifying mRNA COVID-19 vaccine drives strong protective immunity in non-human primates against SARS-CoV-2 infection.

Nat Commun. 2022-6-7

[8]
Optimization of DOTAP/chol Cationic Lipid Nanoparticles for mRNA, pDNA, and Oligonucleotide Delivery.

AAPS PharmSciTech. 2022-5-9

[9]
Advances in Nanoparticles for Effective Delivery of RNA Therapeutics.

Biochip J. 2022

[10]
A Review of Liposomes as a Drug Delivery System: Current Status of Approved Products, Regulatory Environments, and Future Perspectives.

Molecules. 2022-2-17

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