Ling D, Shield L S, Rinehart K L
J Antibiot (Tokyo). 1986 Mar;39(3):345-53. doi: 10.7164/antibiotics.39.345.
A new antibiotic, crisamicin A, with in vitro activity against Gram-positive bacteria, B16 murine melanoma cells, and herpes simplex, vaccinia, and vesicular stomatitis viruses, has been isolated from Micromonospora purpureochromogenes subsp. halotolerans. On the basis of 1H and 13C NMR spectroscopic, high resolution field desorption mass spectrometric, and circular dichroism studies of the antibiotic and several of its derivatives, the structure of crisamicin A has been assigned.
一种新的抗生素——紫霉素A，对革兰氏阳性菌、B16小鼠黑色素瘤细胞以及单纯疱疹病毒、痘苗病毒和水疱性口炎病毒具有体外活性，已从耐盐紫色小单孢菌亚种中分离出来。基于该抗生素及其几种衍生物的1H和13C核磁共振光谱、高分辨率场解吸质谱以及圆二色性研究，已确定了紫霉素A的结构。
