Center for Research in Inflammatory Diseases (CRID), Ribeirão Preto Medical School, Department of Pharmacology, University of São Paulo, Ribeirão Preto, SP, Brazil.
Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Ribeirão Preto, SP, Brazil.
Front Immunol. 2023 Mar 17;14:1137635. doi: 10.3389/fimmu.2023.1137635. eCollection 2023.
Multiple sclerosis is a severe demyelinating disease mediated by cells of the innate and adaptive immune system, especially pathogenic T lymphocytes that produce the pro-inflammatory cytokine granulocyte-macrophage colony stimulating factor (GM-CSF). Although the factors and molecules that drive the genesis of these cells are not completely known, some were discovered and shown to promote the development of such cells, such as dietary factors. In this regard, iron, the most abundant chemical element on Earth, has been implicated in the development of pathogenic T lymphocytes and in MS development its effects on neurons and glia. Therefore, the aim of this paper is to revise the state-of-art regarding the role of iron metabolism in cells of key importance to MS pathophysiology, such as pathogenic CD4 T cells and CNS resident cells. Harnessing the knowledge of iron metabolism may aid in the discovery of new molecular targets and in the development of new drugs that tackle MS and other diseases that share similar pathophysiology.
多发性硬化症是一种由先天和适应性免疫系统细胞介导的严重脱髓鞘疾病，特别是产生促炎细胞因子粒细胞-巨噬细胞集落刺激因子 (GM-CSF) 的致病性 T 淋巴细胞。尽管导致这些细胞产生的因素和分子尚不完全清楚，但已发现并证实某些因素可促进此类细胞的发育，例如饮食因素。在这方面，铁是地球上最丰富的化学元素，它与致病性 T 淋巴细胞的发育以及 MS 及其对神经元和神经胶质的影响有关。因此，本文的目的是复习铁代谢在对 MS 病理生理学具有重要意义的关键细胞中的作用，例如致病性 CD4 T 细胞和中枢神经系统驻留细胞。利用铁代谢的知识可能有助于发现新的分子靶点，并开发针对 MS 和其他具有相似病理生理学的疾病的新药。
