Department of Pharmaceutical Technology, University College of Engineering, Bharathidasan Institute of Technology Campus, Anna University, Tiruchirappalli 620 024, Tamilnadu, India.
Department of Pharmaceutical Technology, University College of Engineering, Bharathidasan Institute of Technology Campus, Anna University, Tiruchirappalli 620 024, Tamilnadu, India.
Regul Toxicol Pharmacol. 2018 Feb;92:182-188. doi: 10.1016/j.yrtph.2017.12.001. Epub 2017 Dec 9.
Terminalia chebula fruits are one of the richest sources of hydrolysable tannins and it is well known medicinal agent in traditional systems of medicine for treatment of various chronic ailments. In the present study, hydrolysable tannin rich fraction (HTF) was isolated from 80% hydroalcoholic extract of Terminalia chebula fruit pericarps and it was studied for acute and repeated dose oral toxicity in Wistar albino rats. HTF did not show any toxic symptoms or mortality at single dose administration of 5000 mg/kg/p.o followed by observation for 14 days. On repeated dose 28 days oral toxicity study, administration of HTF at 1000 mg/kg showed marked reduction in body weight, food intake and water intake when compared with vehicle control. It was also observed that HTF could increase serum urea, glucose and AST level significantly when compared with vehicle control indicating mild disturbances in liver and kidney functions. On histopathological screening, HTF treatment showed a mild granulomatous inflammation in the liver and all other organs remained normal. It was concluded that following 28 days repeated dose oral administration, HTF caused mild disturbances in liver and kidney function which was indicated by reduced body weight, food and water intake, serum parameters and histological observations.
诃子果实是水解单宁含量最丰富的来源之一，在传统医学中是治疗各种慢性疾病的良药。在本研究中，从诃子果皮的 80%水醇提取物中分离出富含水解单宁的馏分（HTF），并在 Wistar 白化大鼠中进行了急性和重复剂量口服毒性研究。在单次给予 5000mg/kg/p.o 剂量后，HTF 未显示任何毒性症状或死亡率，随后观察 14 天。在重复剂量 28 天口服毒性研究中，与载体对照组相比，HTF 以 1000mg/kg 的剂量给药时，体重、食物和水摄入量明显减少。还观察到，与载体对照组相比，HTF 可显著增加血清尿素、葡萄糖和 AST 水平，表明肝肾功能轻度紊乱。在组织病理学筛选中，HTF 治疗显示肝脏有轻度的肉芽肿性炎症，所有其他器官均正常。结论是，在重复 28 天口服给药后，HTF 引起肝肾功能轻度紊乱，这表现为体重、食物和水摄入量减少，血清参数和组织学观察异常。
