Penning Louis C, van den Boom Robin
Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.
Front Vet Sci. 2023 Mar 17;10:1032835. doi: 10.3389/fvets.2023.1032835. eCollection 2023.
First year medical and veterinary students are made very aware that drugs can have very different effects in various species or even in breeds of one specific species. On the other hand, the "One Medicine" concept implies that therapeutic and technical approaches are exchangeable between man and animals. These opposing views on the (dis)similarities between human and veterinary medicine are magnified in regenerative medicine. Regenerative medicine promises to stimulate the body's own regenerative capacity activation of stem cells and/or the application of instructive biomaterials. Although the potential is enormous, so are the hurdles that need to be overcome before large scale clinical implementation is realistic. It is in the advancement of regenerative medicine that veterinary regenerative medicine can play an instrumental and crucial role. This review describes the discovery of (adult) stem cells in domesticated animals, mainly cats and dogs. The promise of cell-mediated regenerative veterinary medicine is compared to the actual achievements, and this will lead to a set of unanswered questions (controversies, research gaps, potential developments in relation to fundamental, pre-clinical, and clinical research). For veterinary regenerative medicine to have impact, either for human medicine and/or for domesticated animals, answering these questions is pivotal.
医学和兽医学专业的一年级学生都非常清楚，药物在不同物种甚至同一特定物种的不同品种中可能会产生非常不同的效果。另一方面，“同一医学”概念意味着治疗方法和技术手段在人和动物之间是可以互换的。在再生医学领域，关于人类医学和兽医学（不）相似性的这些对立观点被放大了。再生医学有望激发人体自身的再生能力——激活干细胞和/或应用具有指导作用的生物材料。尽管潜力巨大，但在大规模临床应用成为现实之前，需要克服的障碍也同样巨大。在再生医学的发展过程中，兽医再生医学可以发挥重要且关键的作用。这篇综述描述了在驯养动物，主要是猫和狗中（成年）干细胞的发现。将细胞介导的再生兽医学的前景与实际成果进行了比较，这将引出一系列未解决的问题（争议、研究空白、与基础研究、临床前研究和临床研究相关的潜在发展）。为了使兽医再生医学产生影响，无论是对人类医学还是对驯养动物，回答这些问题都至关重要。
