Witt C, Stuckey M S, Woolcock A J, Dawkins R L
J Allergy Clin Immunol. 1986 May;77(5):698-702. doi: 10.1016/0091-6749(86)90413-6.
Bronchial responsiveness to histamine and skin prick test reactions to airborne allergens were measured in a random population sample of 891 adults and 1293 schoolchildren. Total serum IgE concentrations were measured in a subset of 389 adults. The prevalence of bronchial histamine responsiveness (BHR) in the adults increased from 5.8% in those who did not respond to allergen prick tests to 22.2% in those who responded to all five allergen groups (p less than 0.00001). Similarly, the prevalence of BHR in the children increased progressively from 3.5% to 35.3% as the number of positive allergen responses increased from zero through five (p less than 0.0001). In adults for whom IgE data were also available, those with BHR had a significantly higher total serum IgE concentration (p less than 0.002).
对891名成年人和1293名学童的随机人群样本测量了支气管对组胺的反应性以及对空气传播变应原的皮肤点刺试验反应。对389名成年人的一个子集测量了总血清IgE浓度。成年人中支气管组胺反应性（BHR）的患病率从不对变应原点刺试验有反应者中的5.8%增加到对所有五个变应原组有反应者中的22.2%（p<0.00001）。同样，随着变应原阳性反应数量从零增加到五个，儿童中BHR的患病率从3.5%逐渐增加到35.3%（p<0.0001）。在也有IgE数据的成年人中，有BHR者的总血清IgE浓度显著更高（p<0.002）。
