López M, Castrillón M A, Tchernitchin A N
J Endocrinol. 1986 Apr;109(1):89-95. doi: 10.1677/joe.0.1090089.
Oestrogen induces a migration of eosinophil leukocytes to the uterus where, it is suggested, these cells mediate several responses to hormone stimulation. To investigate the mechanism of the recognition of the uterus by the eosinophils, the present study describes the effect of a blockade of the rat reticulo-endothelial system with colloidal carbon on oestrogen-induced uterine eosinophilia, and other responses to oestrogen stimulation that, it has been suggested, are mediated by eosinophils. In the absence of oestrogen colloidal carbon induced an increase in the number of eosinophils in mesometrium but not in endometrium with myometrium, and a slight oedematous reaction in deep endometrium. Colloidal carbon abolished the oestrogen-induced increase in the number of eosinophils in endometrium with myometrium and drastically decreased the oestrogen-induced increase in uterine wet weight and the endometrial oedematous responses 6 h after the administration of oestrogen. The present results agree with the hypothesis that most uterine water imbibition is mediated by eosinophils and suggest a possible mechanism for the interaction of colloidal carbon with eosinophil migration to the uterus.
雌激素会诱导嗜酸性白细胞迁移至子宫，据推测，这些细胞会介导对激素刺激的多种反应。为了研究嗜酸性粒细胞识别子宫的机制，本研究描述了用胶体碳阻断大鼠网状内皮系统对雌激素诱导的子宫嗜酸性粒细胞增多以及其他对雌激素刺激的反应（据推测这些反应由嗜酸性粒细胞介导）的影响。在没有雌激素的情况下，胶体碳会导致子宫系膜中嗜酸性粒细胞数量增加，但子宫肌层内膜中的嗜酸性粒细胞数量并未增加，且深层子宫内膜会出现轻微的水肿反应。胶体碳消除了雌激素诱导的子宫肌层内膜中嗜酸性粒细胞数量的增加，并在给予雌激素6小时后大幅降低了雌激素诱导的子宫湿重增加和子宫内膜水肿反应。目前的结果与大多数子宫吸水由嗜酸性粒细胞介导的假设一致，并提示了胶体碳与嗜酸性粒细胞向子宫迁移相互作用的一种可能机制。
