Tchernitchin A, Rooryck J, Tchernitchin X, Vandenhende J, Galand P
Mol Cell Endocrinol. 1975 May;2(5):331-7. doi: 10.1016/0303-7207(75)90020-9.
The effects of cortisol on several oestrogenic responses of the rat uterus were measured. Whether injected i.v., simultaneously with oestradiol-17 beta, or i.p,, 12 h before the oestradiol, cortisol had no effects on the oestrogen-induced increases in uterine glycogen, protein and DNA contents. In contrast, cortisol inhibited both uterine eosinophilia and the increase of wet weight. Both responses show the same higher sensitivity to i.v. injection than to i.p. injection of cortisol. Inhibition of both responses by cortisol follows identical dose-response curves. These data support our hypothesis that the water-imbibition effect of oestrogen i- mediated by uterine eosinophilia and is thus related to the eosinophil receptor system.
测定了皮质醇对大鼠子宫几种雌激素反应的影响。无论是静脉注射（与17β-雌二醇同时注射）还是腹腔注射（在雌二醇注射前12小时），皮质醇对雌激素诱导的子宫糖原、蛋白质和DNA含量增加均无影响。相反，皮质醇抑制子宫嗜酸性粒细胞增多和湿重增加。这两种反应对静脉注射皮质醇的敏感性均高于腹腔注射。皮质醇对这两种反应的抑制遵循相同的剂量-反应曲线。这些数据支持了我们的假设，即雌激素的吸水作用是由子宫嗜酸性粒细胞增多介导的，因此与嗜酸性粒细胞受体系统有关。
