Tchernitchin X, Tchernitchin A, Galand P
Differentiation. 1976 Jun 4;5(2-3):151-4. doi: 10.1111/j.1432-0436.1976.tb00906.x.
To investigase the role of the eosinophil leukocytes in the early oestrogenic responses in the uterus, the kinetics of oestrogen-induced uterine eosinophilia and other parameters of oestrogen stimulation were studied at very early times. Uterine eosinophils increase as early as 5 min after an intravenous injection of oestradiol to immature rats, much earlier than several other changes in the early parameters of oestrogen stimulation. Large number of uterine eosinophils are found attached to the wall of small uterine blood vessels at early times. To elucidate the mechanisms involved in the specific attraction of eosinophils to the uterus in the presence of oestrogens, the in vivo localisation of oestrogens in the rat uterus at early times was studied using a radioautographic technique. Oestrogen receptors were found in the surface of eosinophils and in the wall of small uterine blood vessels. This simultaneous presence of both oestrogen receptors is proposed to explain the specific attachment of eosinophils to uterine blood vessels in the presence of oestrogens, which is the initial step toward eosinophil penetration into the uterus.
为研究嗜酸性粒细胞在子宫早期雌激素反应中的作用，在非常早期的时间点研究了雌激素诱导的子宫嗜酸性粒细胞增多的动力学以及雌激素刺激的其他参数。对未成熟大鼠静脉注射雌二醇后，子宫嗜酸性粒细胞早在5分钟就开始增加，比雌激素刺激早期参数的其他几种变化要早得多。早期发现大量子宫嗜酸性粒细胞附着在子宫小血管壁上。为阐明在雌激素存在下嗜酸性粒细胞向子宫特异性趋化的机制，采用放射自显影技术研究了早期大鼠子宫中雌激素的体内定位。在嗜酸性粒细胞表面和子宫小血管壁中发现了雌激素受体。雌激素受体的这种同时存在被认为可以解释在雌激素存在下嗜酸性粒细胞与子宫血管的特异性附着，这是嗜酸性粒细胞渗透到子宫的第一步。
