Meyer G A, Maiman D J, Edelhauser H F, Lorenzetti O J, Garancis J
J Neurosurg. 1986 Jun;64(6):911-7. doi: 10.3171/jns.1986.64.6.0911.
BSS Plus is a pH-stable balanced salt solution similar to glutathione bicarbonate Ringer's solution. Extensively used in ophthalmology, it is of potential value in neurosurgery. In comparative tests of its effectiveness, 28 cats underwent bilateral irrigation of the surface of the cerebral cortex with normal saline on one side and BSS Plus on the other. After 2 hours, a marked decrease was seen in the surface pH of the hemisphere irrigated with normal saline but not of the hemisphere treated with BSS Plus. Blood-brain barrier changes (measured with Evans blue dye techniques) were more evident following saline irrigation. Somatosensory evoked potentials and cerebral blood flow were not significantly altered. Conventional light microscopy using three standard stains did not reveal a significant difference. Transmission electron microscopy studies were performed in 14 animals and scanning electron microscopy in six. In five animals both transmission and scanning electron microscopy studies were conducted after irrigation with both agents without a cottonoid cover and with immediate harvest of superficial layers from the living brain and immersion-fixation in glutaraldehyde. Tissue preservation was superior on the BSS Plus side in all studies. This agent may represent an improved irrigation solution for neurosurgery, but further studies are required.
BSS Plus是一种pH值稳定的平衡盐溶液，类似于谷胱甘肽碳酸氢盐林格氏溶液。它在眼科广泛使用，在神经外科手术中具有潜在价值。在其有效性的对比试验中，28只猫一侧大脑皮质表面用生理盐水冲洗，另一侧用BSS Plus冲洗。2小时后，用生理盐水冲洗的半球表面pH值显著下降，而用BSS Plus处理的半球则没有。（用伊文思蓝染料技术测量的）血脑屏障变化在生理盐水冲洗后更明显。体感诱发电位和脑血流量没有明显改变。使用三种标准染色的传统光学显微镜检查未发现显著差异。对14只动物进行了透射电子显微镜研究，对6只动物进行了扫描电子显微镜研究。在5只动物中，在用两种药物冲洗且不覆盖棉片后，立即从活脑采集表层并浸入戊二醛进行固定，然后进行透射和扫描电子显微镜研究。在所有研究中，BSS Plus一侧的组织保存情况更好。这种药物可能是一种改进的神经外科冲洗液，但还需要进一步研究。
