Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Department of Physiotherapy, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran.
BMC Res Notes. 2023 Apr 4;16(1):45. doi: 10.1186/s13104-023-06316-z.
To re-explore the responsiveness of the Persian version of Multiple Sclerosis Walking Scale-12 (MSWS-12p) to physiotherapy intervention and determine the minimally clinically important change (MCIC). This study followed a prospective cohort design. Patients with MS (PwMS) underwent physiotherapy treatment for 10 sessions. The outcome measures were the MSWS-12p and Timed 25-Foot Walk test (T25-FW). Data was collected before and after ten sessions of physiotherapy. The effect sizes and the area under receiver operating characteristics curve (AUC) and MCIC were calculated.
Thirty PwMS (16 female, mean age 43.07 years) participated in the study. The effect sizes for MSWS-12p were moderate (0.52, 0.64). The change scores of MSWS-12p showed excellent correlation with the dichotomized smallest detectable change (SDC) criterion (Eta coefficient test = 0.84). There was no correlation between the MSWS-12p total change scores and the T25-FW (r = - 0.14, p = 0.45). The AUC was perfect and the MCIC for the MSWS-12p was calculated 10.0 points. The MSWS-12p is responsive and demonstrates changes after physiotherapy. Changes > 10.0 points on MSWS-12p total score should be considered as true improvement after physiotherapy.
重新探讨波斯语多发性硬化行走量表 12 版（MSWS-12p）对物理治疗干预的反应性，并确定最小临床重要变化（MCIC）。本研究采用前瞻性队列设计。多发性硬化症患者（PwMS）接受 10 次物理治疗。结局指标为 MSWS-12p 和 25 英尺计时步行测试（T25-FW）。数据在 10 次物理治疗前后收集。计算了效应大小和受试者工作特征曲线下的面积（AUC）和 MCIC。
30 名 PwMS（16 名女性，平均年龄 43.07 岁）参与了研究。MSWS-12p 的效应大小为中度（0.52，0.64）。MSWS-12p 的变化评分与二分最小可检测变化（SDC）标准呈极好的相关性（Eta 系数检验=0.84）。MSWS-12p 总变化评分与 T25-FW 之间无相关性（r=-0.14，p=0.45）。AUC 为完美，MSWS-12p 的 MCIC 计算为 10.0 分。MSWS-12p 具有反应性，并在物理治疗后显示出变化。MSWS-12p 总分变化>10.0 分应被视为物理治疗后真正的改善。
