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大环内酯类抗生素激活整合应激反应并促进肿瘤增殖。

Macrolide antibiotics activate the integrated stress response and promote tumor proliferation.

作者信息

Yu Xin, Tian Ai-Ling, Wang Ping, Li Juanjuan, Wu Juan, Li Bei, Liu Zhou, Liu Siqing, Gao Zhijie, Sun Si, Sun Shengrong, Tu Yi, Wu Qi

机构信息

Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, P. R. China.

Gustave Roussy Cancer Campus, Villejuif Cedex, France.

出版信息

Cell Stress. 2023 Mar 21;7(4):20-33. doi: 10.15698/cst2023.04.278. eCollection 2023 Apr.

DOI:10.15698/cst2023.04.278
PMID:37021084
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10069438/
Abstract

Macrolide antibiotics are widely used antibacterial agents that are associated with autophagy inhibition. This study aimed to investigate the association between macrolide antibiotics and malignant tumors, as well as the effect on autophagy, reactive oxygen species (ROS) accumulation and integrated stress response (ISR). The meta-analysis indicated a modestly higher risk of cancer in macrolide antibiotic ever-users compared to non-users. Further experiments showed that macrolides block autophagic flux by inhibiting lysosomal acidification. Additionally, azithromycin, a representative macrolide antibiotic, induced the accumulation of ROS, and stimulated the ISR and the activation of transcription factor EB (TFEB) and TFE3 in a ROS-dependent manner. Finally, animal experiments confirmed that azithromycin promoted tumor progression , which could be receded by N-acetylcysteine, an inhibitor of ROS and ISR. Overall, this study reveals the potential role of macrolide antibiotics in malignant progression and highlights the need for further investigation into their effects.

摘要

大环内酯类抗生素是广泛使用的抗菌剂，与自噬抑制有关。本研究旨在探讨大环内酯类抗生素与恶性肿瘤之间的关联，以及对自噬、活性氧（ROS）积累和综合应激反应（ISR）的影响。荟萃分析表明，与未使用大环内酯类抗生素的人相比，曾经使用过该类抗生素的人患癌症的风险略高。进一步的实验表明，大环内酯类药物通过抑制溶酶体酸化来阻断自噬流。此外，代表性的大环内酯类抗生素阿奇霉素可诱导ROS积累，并以ROS依赖的方式刺激ISR以及转录因子EB（TFEB）和TFE3的激活。最后，动物实验证实阿奇霉素促进肿瘤进展，而ROS和ISR抑制剂N-乙酰半胱氨酸可以缓解这种进展。总体而言，本研究揭示了大环内酯类抗生素在恶性进展中的潜在作用，并强调需要进一步研究其影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b75/10069438/3ca6f20867d9/ces-07-020-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b75/10069438/06c7c0205955/ces-07-020-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b75/10069438/06c2ace27ae3/ces-07-020-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b75/10069438/bd2614cb5fec/ces-07-020-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b75/10069438/bf77280a1e04/ces-07-020-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b75/10069438/db0937321bfb/ces-07-020-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b75/10069438/3ca6f20867d9/ces-07-020-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b75/10069438/06c7c0205955/ces-07-020-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b75/10069438/d824a8501f83/ces-07-020-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b75/10069438/06c2ace27ae3/ces-07-020-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b75/10069438/bd2614cb5fec/ces-07-020-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b75/10069438/bf77280a1e04/ces-07-020-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b75/10069438/db0937321bfb/ces-07-020-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b75/10069438/3ca6f20867d9/ces-07-020-g007.jpg

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2
Antibiotic Azithromycin inhibits brown/beige fat functionality and promotes obesity in human and rodents.抗生素阿奇霉素抑制人及啮齿动物棕色/米色脂肪功能并促进肥胖。
Theranostics. 2022 Jan 1;12(3):1187-1203. doi: 10.7150/thno.63067. eCollection 2022.
3
Full-coverage regulations of autophagy by ROS: from induction to maturation.
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J Cancer. 2024 May 28;15(12):3873-3889. doi: 10.7150/jca.96491. eCollection 2024.
4
Novel insights at the crossroads of antibiotic use and cancer risk.抗生素使用与癌症风险交叉点上的新见解。
Cell Stress. 2023 May 25;7(6):46-49. doi: 10.15698/cst2023.06.280. eCollection 2023 Jun.
ROS 对自噬的全面调控：从诱导到成熟。
Autophagy. 2022 Jun;18(6):1240-1255. doi: 10.1080/15548627.2021.1984656. Epub 2021 Oct 18.
4
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