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采用过继细胞转移免疫疗法治疗实体上皮癌患者。

Adoptive cell transfer immunotherapy for patients with solid epithelial cancers.

机构信息

Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

出版信息

Cancer Cell. 2023 Apr 10;41(4):646-648. doi: 10.1016/j.ccell.2023.03.003.

DOI:10.1016/j.ccell.2023.03.003
PMID:37037613
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10184665/
Abstract

Efforts to apply adoptive cell transfer (ACT) immunotherapy to patients with common epithelial cancers have been stimulated by the demonstration that the majority of these patients contain lymphocytes reactive against the expressed products of their cancer mutations. Early efforts to specifically target these antigens have been promising.

摘要

采用细胞转移（ACT）免疫疗法治疗常见上皮癌患者的努力受到了鼓舞，因为大多数此类患者含有针对其癌症突变表达产物的反应性淋巴细胞。早期针对这些抗原的靶向治疗努力是有希望的。

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本文引用的文献

[1]
Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma.

N Engl J Med. 2022-12-8

[2]
Adoptive Cellular Therapy with Autologous Tumor-Infiltrating Lymphocytes and T-cell Receptor-Engineered T Cells Targeting Common p53 Neoantigens in Human Solid Tumors.

Cancer Immunol Res. 2022-8-3

[3]
Neoantigen T-Cell Receptor Gene Therapy in Pancreatic Cancer.

N Engl J Med. 2022-6-2

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Cancer Cell. 2022-5-9

[5]
Neoantigen Identification and Response to Adoptive Cell Transfer in Anti-PD-1 Naïve and Experienced Patients with Metastatic Melanoma.

Clin Cancer Res. 2022-7-15

[6]
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Science. 2022-2-25

[7]
Breast Cancers Are Immunogenic: Immunologic Analyses and a Phase II Pilot Clinical Trial Using Mutation-Reactive Autologous Lymphocytes.

J Clin Oncol. 2022-6-1

[8]
Impact of Prior Treatment on the Efficacy of Adoptive Transfer of Tumor-Infiltrating Lymphocytes in Patients with Metastatic Melanoma.

Clin Cancer Res. 2021-10-1

[9]
Identification and Validation of T-cell Receptors Targeting Hotspot Mutations in Human Cancers for Use in Cell-based Immunotherapy.

Clin Cancer Res. 2021-9-15

[10]
Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer.

Science. 2020-12-11

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