Madkhali Aymen M, Mobarki Abdullah A, Ghzwani Ahmad H, Al-Mekhlafi Hesham M, Zhranei Ahmed, Osais Abdulrahman, Sohel Ahmed, Othman Basim, Dobie Gasim, Hamali Hassan A
Department of Medical Laboratory Technology, College of Applied Medical Sciences, Jazan University, Gizan, Saudi Arabia.
Medical Research Center, Jazan University, Gizan, Saudi Arabia.
Int J Gen Med. 2023 Apr 5;16:1205-1215. doi: 10.2147/IJGM.S402212. eCollection 2023.
Procoagulant microvesicles (MVs) are submicron membrane fragments released from activated cells and cells undergoing apoptosis. The procoagulant activity of MVs is enhanced in the presence of tissue factor (TF). MVs and TF are active mediators that induce pro-inflammatory response and prothrombotic tendency and have been linked to the severity of several disorders, including malaria infection. The current study aimed to measure the levels of circulating procoagulant MVs and TF-bearing MVs in malaria patients and correlate these levels with other hematological parameters and parasitemia.
Levels of MVs and TF-bearing MVs in the plasma of children and adult patients infected with were measured alongside matched healthy controls.
Patients with infection had ~3.8 times MVs (p < 0.0001) and ~13.0 times TF-bearing MVs compared to the matched healthy controls. MVs showed inverse significant correlation with platelet count (p = 0.0055), hemoglobin (p = 0.0004) and parasitemia.
Elevated levels of MVs and TF-bearing MVs could be useful biomarkers to evaluate the procoagulant activity, inflammatory response and parasitemia levels in malaria infection, aiding in better management of the disease.
促凝微泡（MVs）是从活化细胞和正在经历凋亡的细胞释放的亚微米级膜碎片。在组织因子（TF）存在的情况下，MVs的促凝活性会增强。MVs和TF是诱导促炎反应和血栓形成倾向的活性介质，并且与包括疟疾感染在内的几种疾病的严重程度有关。当前的研究旨在测量疟疾患者循环促凝MVs和携带TF的MVs的水平，并将这些水平与其他血液学参数和寄生虫血症相关联。
在匹配的健康对照的同时，测量感染[此处原文缺失具体感染类型]的儿童和成年患者血浆中MVs和携带TF的MVs的水平。
与匹配的健康对照相比，感染[此处原文缺失具体感染类型]的患者的MVs约为3.8倍（p < 0.0001），携带TF的MVs约为13.0倍。MVs与血小板计数（p = 0.0055）、血红蛋白（p = 0.0004）和寄生虫血症呈显著负相关。
MVs和携带TF的MVs水平升高可能是评估疟疾感染中促凝活性、炎症反应和寄生虫血症水平的有用生物标志物，有助于更好地管理该疾病。
