Center of Clinical and Preclinical Research MEDIPARK, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Trieda SNP 1, 040 11 Košice, Slovakia.
Int J Mol Sci. 2023 Mar 27;24(7):6292. doi: 10.3390/ijms24076292.
Cardiovascular diseases are the main cause of death in many countries, and the better prevention and prediction of these diseases would be of great importance for individuals and society. Nutrition, the gut microbiota, and metabolism have raised much interest in the field of cardiovascular disease research in the search for the main mechanisms that promote cardiovascular diseases. Understanding the interactions between dietary nutrient intake and the gut microbiota-mediated metabolism may provide clinical insight in order to identify individuals at risk of cardiometabolic disease progression, as well as other potential therapeutic targets to mitigate the risk of cardiometabolic disease progression. The development of cardiometabolic diseases can be modulated by specific beneficial metabolites derived from bacteria. Therefore, it is very important to investigate the impact of these metabolites on human health and the possibilities of modulating their production with dietary supplements called biotics.
心血管疾病是许多国家的主要死亡原因，更好地预防和预测这些疾病对个人和社会都具有重要意义。在寻找促进心血管疾病的主要机制的过程中，营养、肠道微生物群和代谢引起了心血管疾病研究领域的极大兴趣。了解饮食营养素摄入与肠道微生物群介导的代谢之间的相互作用，可能为临床提供见解，以识别有发生代谢性心血管疾病进展风险的个体，以及其他潜在的治疗靶点来降低发生代谢性心血管疾病进展的风险。心血管代谢疾病的发展可以通过源自细菌的特定有益代谢物来调节。因此，研究这些代谢物对人类健康的影响以及通过膳食补充剂（称为生物制剂）来调节其产生的可能性非常重要。
