Zhang Jingchi, Fan Jiakun, Luo Hui, Liang Zhengwei, Guan Yanhui, Lei Xin, Bo Nianguo, Zhao Ming
National-Local Joint Engineering Research Center on Gemplasm lnnovation & Uilization of Chinese Medicinal Materials in Southwest China, The Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural University, Kunming 650201, China.
Yunnan Characteristic Plant Extraction Laboratory, Kunming 650106, China.
Foods. 2023 Mar 28;12(7):1428. doi: 10.3390/foods12071428.
Alcoholic fatty liver disease (AFLD) is caused by long-term heavy alcohol consumption; therefore, useful and practical methods for the prevention of AFLD are urgently needed. The edible flower of contains diverse flavonoids, and has shown antioxidant activity as well as antihypertensive and anti-inflammatory effects. In this study, an AFLD model was established, the protective effect of flower (DOF) ethanol extract on AFLD was evaluated, and its mechanisms were investigated by analyzing gut microbiota and short-chain fatty acids (SCFAs). DOF extract (DOFE) supplementation promoted alcohol metabolism, restored hepatic antioxidant capacity, alleviated oxidative stress, reduced inflammatory factor levels, and inhibited dyslipidemia induced by alcohol intake in chronic alcohol-exposed mice, especially in the high DOFE group. Moreover, DOFE supplementation increased the diversity, structure, and composition of the gut microbiota in mice, restored some of the abnormal SCFA levels caused by AFLD, and helped restore intestinal function. DOFE supplementation significantly increased the relative abundance of , suggesting that may be a potential target of the protective effect of DOFE. Therefore, DOFE supplementation to improve the composition of the gut microbiota may be an effective therapeutic strategy for the prevention of AFLD.
酒精性脂肪肝（AFLD）是由长期大量饮酒引起的；因此，迫切需要实用有效的AFLD预防方法。[具体植物名称]的可食用花朵含有多种黄酮类化合物，并已显示出抗氧化活性以及降压和抗炎作用。在本研究中，建立了AFLD模型，评估了[具体植物名称]花（DOF）乙醇提取物对AFLD的保护作用，并通过分析肠道微生物群和短链脂肪酸（SCFAs）来研究其作用机制。补充DOF提取物（DOFE）可促进酒精代谢，恢复肝脏抗氧化能力，减轻氧化应激，降低炎症因子水平，并抑制慢性酒精暴露小鼠因饮酒引起的血脂异常，尤其是在高剂量DOFE组中。此外，补充DOFE增加了小鼠肠道微生物群的多样性、结构和组成，恢复了一些由AFLD引起的异常SCFA水平，并有助于恢复肠道功能。补充DOFE显著增加了[具体微生物名称]的相对丰度，表明[具体微生物名称]可能是DOFE保护作用的潜在靶点。因此，补充DOFE以改善肠道微生物群的组成可能是预防AFLD的有效治疗策略。
