Brink Christiaan B, Lewis David I
Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom 2531, South Africa.
School of Biomedical Sciences & Biological Sciences Teaching Innovation Hub, University of Leeds, Leeds LS2 9JT, UK.
Animals (Basel). 2023 Mar 23;13(7):1128. doi: 10.3390/ani13071128.
Animal research ethics and animal welfare in science have become progressively tightly regulated, and ethical integrity and scientific quality, as well as social responsiveness and responsibility have become key requirements for research to be approved, funded, published, and accepted. The multitude of factors to contemplate has in some instances not only become complex, requiring a team approach, but often perceived as confusing and overwhelming. To facilitate a process of simplistic yet comprehensive conceptualization, we developed the 12 Rs Framework to act as a mind map to guide scientists, oversight structures, and other stakeholders through the myriad of ethical considerations. It unfolds into three domains of twelve encompassing ethical principles, values, and other considerations, including the animal welfare, social values, and scientific integrity domains, whilst also recognizing the diversity of local context, legal requirements, values, and cultures around the globe. In the end, it can be seen as a unifying ethical framework to foster and promote animal research ethics.
科学领域中的动物研究伦理与动物福利监管日益严格，伦理完整性、科学质量以及社会响应性和责任感已成为研究获得批准、资助、发表和认可的关键要求。需要考虑的众多因素在某些情况下不仅变得复杂，需要团队协作，而且常常让人感到困惑和难以应对。为了促进一个简单而全面的概念化过程，我们开发了“12R框架”，作为一个思维导图，引导科学家、监督机构和其他利益相关者应对众多伦理考量。它展开为包含伦理原则、价值观和其他考量的三个领域，共十二个方面，包括动物福利、社会价值观和科学诚信领域，同时也认识到全球各地当地背景、法律要求、价值观和文化的多样性。最后，它可被视为一个促进和推动动物研究伦理的统一伦理框架。
