Camacho Moll Maria Elena, Mata Tijerina Viviana Leticia, Silva Ramírez Beatriz, Peñuelas Urquides Katia, González Escalante Laura Adiene, Escobedo Guajardo Brenda Leticia, Cruz Luna Jorge Eleazar, Corrales Pérez Roberto, Gómez García Salvador, Bermúdez de León Mario
Laboratory of Molecular Biology, Northeast Biomedical Research Centre, Mexican Social Security Institute, Monterrey 64720, Mexico.
Laboratory of Immunogenetics, Northeast Biomedical Research Centre, Mexican Social Security Institute, Monterrey 64720, Mexico.
J Clin Med. 2023 Apr 3;12(7):2676. doi: 10.3390/jcm12072676.
People with comorbidities and the male sex are at a higher risk of developing severe COVID-19. In the present study, we aim to investigate the associated factors for infection, severity, and death due to COVID-19 in a population from Nuevo León, México. Epidemiological COVID-19 data were collected from 65 hospitals from December 2020 to May 2022. A total of 75,232 cases were compiled from which 25,722 cases were positive for SARS-CoV-2. Male sex, older age, diabetes, obesity, and hypertension were associated with infection. In addition to the above-mentioned factors, renal disease, cardiovascular disease, and immunosuppression were found to be associated with increased COVID-19 severity. These factors, as well as neurological diseases, are also associated with death due to COVID-19. When comparing the different variants of SARs-CoV-2, the variant B1.1.519 increased the probability of death by 2.23 times compared to the AY.20 variant. Male sex, older age, diabetes, obesity, and hypertension are associated with SARS-CoV-2 infection, severity, and death. Along with the aforementioned comorbidities, renal disease, cardiovascular disease, and immunosuppression are also associated with severity and death. Another factor associated with death is the presence of neurological disease. The SARS-CoV-2 B1.1.519 variant increases the odds of death compared to the SARS-CoV-2 AY.20 variant.
患有合并症的人群以及男性感染新冠病毒后发展为重症的风险更高。在本研究中，我们旨在调查墨西哥新莱昂州人群中新冠病毒感染、重症及死亡的相关因素。2020年12月至2022年5月期间，我们从65家医院收集了新冠病毒的流行病学数据。共汇总了75232例病例，其中25722例新冠病毒检测呈阳性。男性、高龄、糖尿病、肥胖和高血压与感染相关。除上述因素外，还发现肾病、心血管疾病和免疫抑制与新冠病毒感染重症化相关。这些因素以及神经系统疾病也与新冠病毒感染死亡相关。比较新冠病毒的不同变体时，与AY.20变体相比，B1.1.519变体的死亡概率增加了2.23倍。男性、高龄、糖尿病、肥胖和高血压与新冠病毒感染、重症及死亡相关。除上述合并症外，肾病、心血管疾病和免疫抑制也与重症及死亡相关。另一个与死亡相关的因素是神经系统疾病的存在。与新冠病毒AY.20变体相比，B1.1.519变体增加了死亡几率。
