Rock G, Tittley P, McCombie N
Transfusion. 1986 May-Jun;26(3):269-71. doi: 10.1046/j.1537-2995.1986.26386209385.x.
A plasmapheresis device with both membrane filtration and centrifugation features was tested. The device permits the collection of 500 ml of plasma within 30 minutes; when run at a 1:12.5 ratio with acid-citrate-dextrose (ACD-A) the resultant plasma factor VIII levels were 1.05 units per ml and the albumin was 41 g per l. Free hemoglobin was not detected, and there was no evidence of fibrinopeptide A, prekallikrein, or activation of complement. The plasma had a zero hematocrit value and contained few platelets and white cells. Before and after the procedure, donors and aliquots from the return line did not show any significant effect on cell count or function. This device functioned well to collect plasma for infusion or fractionation and was accepted well by donors. A major advantage is the relatively low cost for the software package ($15.00, US, 1985), which should make plasmapheresis with this device economically feasible.
对一款兼具膜过滤和离心功能的血浆置换设备进行了测试。该设备能够在30分钟内采集500毫升血浆；当与枸橼酸-葡萄糖-酸（ACD-A）以1:12.5的比例运行时，所得血浆中因子VIII水平为每毫升1.05单位，白蛋白为每升41克。未检测到游离血红蛋白，也没有纤维蛋白肽A、前激肽释放酶或补体激活的证据。该血浆的血细胞比容值为零，且几乎不含血小板和白细胞。在该过程前后，供体以及回输管路中的样本对细胞计数或功能均未显示出任何显著影响。该设备在采集用于输注或分离的血浆方面运行良好，且供体对其接受度较高。一个主要优势在于软件包成本相对较低（1985年美国价格为15美元），这使得使用该设备进行血浆置换在经济上可行。
