通过单采获得的少量血浆制备冻干热处理冷沉淀。
Preparation of lyophilized heat-treated cryoprecipitates from a small pool of plasma obtained by apheresis.
作者信息
Allersma D P, Roeffen E, Van der Does J A, Briët E
机构信息
Central Pharmacy of the Hospitals of The Hague, The Netherlands.
出版信息
Pharm Weekbl Sci. 1991 Feb 22;13(1):18-23. doi: 10.1007/BF01963879.
A method was developed for the batch-wise production of small-pool lyophilized heat-treated cryoprecipitates in a regional Blood Bank. Ten vials of final product were derived from twenty 600 g apheresis plasma donations. We found 384 IU of factor VIII per vial and a specific activity of 0.20 IU per mg total protein. Production recovery was 340 IU of factor VIII per kg plasma. The method was easy to perform and gave a product of good quality.
在一家地区血库中开发了一种用于批量生产小池冻干热处理冷沉淀的方法。最终产品的十瓶来自二十份600克单采血浆捐献。我们发现每瓶中有384国际单位的凝血因子VIII，总蛋白的比活性为每毫克0.20国际单位。生产回收率为每千克血浆340国际单位的凝血因子VIII。该方法易于操作，且产品质量良好。
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