Kang Dong-Hee, Choi Jun-Gyu, Lee Won-June, Heo Dongmi, Wang Sungrok, Park Sungjun, Yoon Myung-Han
School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
Electrical and Computer Engineering, Ajou University, Suwon 16499, Republic of Korea.
APL Bioeng. 2023 Apr 10;7(2):026102. doi: 10.1063/5.0138861. eCollection 2023 Jun.
Biocompatible field-effect-transistor-based biosensors have drawn attention for the development of next-generation human-friendly electronics. High-performance electronic devices must achieve low-voltage operation, long-term operational stability, and biocompatibility. Herein, we propose an electrolyte-gated thin-film transistor made of large-area solution-processed indium-gallium-zinc oxide (IGZO) semiconductors capable of directly interacting with live cells at physiological conditions. The fabricated transistors exhibit good electrical performance operating under sub-0.5 V conditions with high on-/off-current ratios (>10) and transconductance (>1.0 mS) over an extended operational lifetime. Furthermore, we verified the biocompatibility of the IGZO surface to various types of mammalian cells in terms of cell viability, proliferation, morphology, and drug responsiveness. Finally, the prolonged stable operation of electrolyte-gated transistor devices directly integrated with live cells provides the proof-of-concept for solution-processed metal oxide material-based direct cellular interfaces.
基于生物相容性场效应晶体管的生物传感器已引起人们对下一代亲人类电子产品开发的关注。高性能电子设备必须实现低电压运行、长期运行稳定性和生物相容性。在此，我们提出一种由大面积溶液处理的铟镓锌氧化物（IGZO）半导体制成的电解质门控薄膜晶体管，该晶体管能够在生理条件下与活细胞直接相互作用。所制备的晶体管在低于0.5 V的条件下工作时表现出良好的电学性能，具有高的开/关电流比（>10）和跨导（>1.0 mS），且工作寿命延长。此外，我们从细胞活力、增殖、形态和药物反应性等方面验证了IGZO表面对各种类型哺乳动物细胞的生物相容性。最后，与活细胞直接集成的电解质门控晶体管器件的长期稳定运行，为基于溶液处理金属氧化物材料的直接细胞界面提供了概念验证。
