Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030 P.R. China.
Pingshan District People's Hospital of Shenzhen, Pingshan General Hospital of Southern Medical University, Shenzhen, 518118 P.R. China.
Theranostics. 2023 Mar 27;13(6):2015-2039. doi: 10.7150/thno.80615. eCollection 2023.
Increasing data reveals that gelatin that has been methacrylated is involved in a variety of physiologic processes that are important for therapeutic interventions. Gelatin methacryloyl (GelMA) hydrogel is a highly attractive hydrogels-based bioink because of its good biocompatibility, low cost, and photo-cross-linking structure that is useful for cell survivability and cell monitoring. Methacrylated gelatin (GelMA) has established itself as a typical hydrogel composition with extensive biomedical applications. Recent advances in GelMA have focused on integrating them with bioactive and functional nanomaterials, with the goal of improving GelMA's physical, chemical, and biological properties. GelMA's ability to modify characteristics due to the synthesis technique also makes it a good choice for soft and hard tissues. GelMA has been established to become an independent or supplementary technology for musculoskeletal problems. Here, we systematically review mechanism-of-action, therapeutic uses, and challenges and future direction of GelMA in musculoskeletal disorders. We give an overview of GelMA nanocomposite for different applications in musculoskeletal disorders, such as osteoarthritis, intervertebral disc degeneration, bone regeneration, tendon disorders and so on.
越来越多的数据表明，已甲基丙烯酰化的明胶参与了多种生理过程，这些过程对治疗干预很重要。明胶甲基丙烯酰（GelMA）水凝胶是一种极具吸引力的基于水凝胶的生物墨水，因为它具有良好的生物相容性、低成本和光交联结构，有利于细胞存活和细胞监测。甲基丙烯酰化明胶（GelMA）已被确立为一种具有广泛生物医学应用的典型水凝胶组成物。最近在 GelMA 方面的进展集中在将其与生物活性和功能纳米材料集成，以提高 GelMA 的物理、化学和生物学特性。GelMA 能够通过合成技术来改变特性，这也使其成为软、硬组织的理想选择。GelMA 已被确立为治疗肌肉骨骼问题的独立或辅助技术。在这里，我们系统地综述了 GelMA 在肌肉骨骼疾病中的作用机制、治疗用途以及挑战和未来方向。我们概述了 GelMA 纳米复合材料在肌肉骨骼疾病中的不同应用，如骨关节炎、椎间盘退变、骨再生、肌腱疾病等。
