Johns Hopkins Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Cancer Discov. 2023 May 4;13(5):1053-1057. doi: 10.1158/2159-8290.CD-23-0277.
Convergence science teams integrating clinical, biological, engineering, and computational expertise are inventing new forecast systems to monitor and predict evolutionary changes in tumor and immune interactions during early cancer progression and therapeutic response. The resulting methods should inform a new predictive medicine paradigm to select adaptive immunotherapeutic regimens personalized to patients' tumors at a given time during their cancer progression for durable patient response.
融合了临床、生物、工程和计算专业知识的转化科学团队正在发明新的预测系统,以监测和预测肿瘤和免疫相互作用在癌症早期进展和治疗反应过程中的进化变化。由此产生的方法应该为一种新的预测医学范式提供信息,以便根据患者癌症进展过程中特定时间的肿瘤情况,为患者选择个体化的适应性免疫治疗方案,从而实现持久的患者反应。