Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Sci Rep. 2023 Apr 17;13(1):6224. doi: 10.1038/s41598-023-33505-4.
The current study aimed to examine the possible association of the dietary index for insulin resistance (DIR) and the lifestyle index for insulin resistance (LIR), determined by dietary components, body mass index, and physical activity, with the risk of cardiometabolic diseases, including insulin resistance (IR), hypertension (HTN), diabetes, and metabolic syndrome (MetS). This prospective cohort study was performed on 2717 individuals aged ≥ 19 years in the framework of the Tehran Lipid-Glucose Study. Data on nutritional intakes were assessed using a validated food frequency questionnaire. Logistic regression models were used to determine the odds ratio and 95% confidence intervals (ORs and 95% CIs) of cardiometabolic diseases across tertiles of DIR and LIR scores. During 3-years of follow-up, the incidence rate of diabetes, IR, HTN, and MetS was 3%, 13%, 13.9%, and 17%, respectively. In the multi-variables model, after controlling all potential confounders, the risk of IR(OR: 1.65, 95% CI 1.01-2.69, P-trend = 0.047), diabetes (OR: 1.95, 95% CI 1.02-3.74, P-trend = 0.058), and HTN(OR: 1.52, 95% CI 1.07-2.15, P-trend = 0.016) was increased across tertiles of DIR score. Also, the risk of IR (OR: 2.85, 95% CI 1.72-4.73, P-trend < 0.001), diabetes(OR: 2.44, 95% CI 1.24-4.78, P-trend = 0.004), HTN(OR: 1.95, 95% CI 1.35-2.81, P-trend < 0.001), and MetS (OR: 2.87, 95% CI 1.96-4.18, P-trend < 0.001) were increased across tertiles of LIR score. Our findings reported that a dietary pattern with a higher DIR score and a lifestyle with a higher LIR score might be related to increased cardiometabolic disorders, including diabetes, HTN, Mets, and IR in Iranian adults.
本研究旨在探讨饮食胰岛素抵抗指数（DIR）和生活方式胰岛素抵抗指数（LIR）与心血管代谢疾病风险的可能关联，这些指数由饮食成分、体重指数和体力活动决定，包括胰岛素抵抗（IR）、高血压（HTN）、糖尿病和代谢综合征（MetS）。这项前瞻性队列研究在德黑兰血脂研究框架内对 2717 名年龄≥19 岁的个体进行。使用经过验证的食物频率问卷评估营养摄入量。使用逻辑回归模型确定 DIR 和 LIR 评分三分位数的心血管代谢疾病的比值比和 95%置信区间（OR 和 95%CI）。在 3 年的随访期间，糖尿病、IR、HTN 和 MetS 的发生率分别为 3%、13%、13.9%和 17%。在多变量模型中，在控制所有潜在混杂因素后，IR（OR：1.65，95%CI 1.01-2.69，P 趋势=0.047）、糖尿病（OR：1.95，95%CI 1.02-3.74，P 趋势=0.058）和 HTN（OR：1.52，95%CI 1.07-2.15，P 趋势=0.016）的风险随着 DIR 评分三分位数的增加而增加。此外，IR（OR：2.85，95%CI 1.72-4.73，P 趋势<0.001）、糖尿病（OR：2.44，95%CI 1.24-4.78，P 趋势=0.004）、HTN（OR：1.95，95%CI 1.35-2.81，P 趋势<0.001）和 MetS（OR：2.87，95%CI 1.96-4.18，P 趋势<0.001）的风险随着 LIR 评分三分位数的增加而增加。我们的研究结果表明，伊朗成年人中，饮食模式具有较高的 DIR 评分和生活方式具有较高的 LIR 评分可能与增加的心血管代谢紊乱有关，包括糖尿病、HTN、Mets 和 IR。
