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微生理系统的新视野:印度在与人类相关的研究中开辟道路。

New horizons of microphysiological systems: India forging its path in human-relevant research.

机构信息

Centre for Predictive Human Model Systems, Atal Incubation Centre-CCMB, Hyderabad 500039, India.

CSIR-Centre for Cellular and Molecular Biology, Hyderabad 500007, India.

出版信息

Biol Open. 2023 Apr 15;12(4). doi: 10.1242/bio.059847. Epub 2023 Apr 18.

Abstract

The past decade has seen expeditious developments in our ability to grow and maintain a variety of human cells and tissues, with properties closely mimicking those in the human body. Prominent researchers and entrepreneurs from all over the world assembled in Hyderabad, India to discuss developments in this field that have not only aided fundamental understanding of organ development and disease processes but have served as good physiological models for toxicity testing and drug development. The speakers presented ingenious, cutting-edge technology and forward-thinking ideas. This report presents the salient aspects of their discussions, highlights the importance of identifying unmet needs, and discusses setting of standards that will help regulatory approvals as we move into a new era, with nominal animal use in research and effective drug discovery.

摘要

过去十年,我们在培养和维持各种具有人体相似特性的人类细胞和组织的能力方面取得了迅速发展。来自世界各地的杰出研究人员和企业家齐聚印度海得拉巴,讨论这一领域的发展。这些发展不仅有助于深入了解器官发育和疾病过程,而且为毒性测试和药物开发提供了良好的生理模型。演讲者展示了巧妙的、前沿的技术和前瞻性的想法。本报告介绍了他们讨论的要点,强调了确定未满足需求的重要性,并讨论了制定标准的问题,因为我们进入一个新的时代,研究中动物使用量很少,药物发现效果显著,这些标准将有助于监管审批。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5eb/10151824/834f7bc32bee/biolopen-12-059847-g1.jpg

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