Department of Pharmacy, Al Maarif University College, Ramadi, Anbar, Iraq.
Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Rev Environ Health. 2023 Apr 19;39(3):539-549. doi: 10.1515/reveh-2022-0245. Print 2024 Sep 25.
In today's society, with the continuous development of manufacturing industries and factories related to chemicals, the amount of heavy metals in the inhaled air of humans, water and even food consumption has increased dramatically. The aim of this study was investigation of relationship between exposure to heavy metals on the increased carcinogenicity risk of kidney and bladder. Databases used to for searched were the Springer, Google Scholar, Web of Science, Science Direct (Scopus) and PubMed. At the end after sieve we selected 20 papers. Identify all relevant studies published 2000-2021. The results of this study showed that exposure to heavy metals due to the bio accumulative properties of these metals can cause kidney and bladder abnormalities and provide the basis through various mechanisms for malignant tumors in these organs. Based on result this study, since a limited number of heavy metals including copper, iron, zinc and nickel in very small amounts as micronutrients play a very important role in the function of enzymes and the body cells biological reactions, but exposure to some of them like arsenic, lead, vanadium and mercury will cause irreversible effects on people's health and cause various diseases including cancers of the liver, pancreas, prostate, breast, kidney and bladder. The kidneys, ureter and bladder are the most important organs in the urinary tract on human. According to the result of this study, the duty of this urinary system is to remove toxins, chemicals and heavy metals from the blood, balance electrolytes, excrete excess fluid, produce urine and transfer it to the bladder. This mechanism causes the kidneys and bladder to be highly associated with these toxins and heavy metals, which can lead to various diseases in these two important organs. According to the finding the reducing exposure to heavy metals in various ways can prevent many diseases related to this system and reduce the incidence of kidney and bladder cancers.
在当今社会，随着制造业和与化学有关的工厂的不断发展，人类吸入的空气、水甚至食物中的重金属含量都大幅增加。本研究的目的是调查重金属暴露与肾脏和膀胱致癌风险增加之间的关系。使用的数据库包括 Springer、Google Scholar、Web of Science、Science Direct（Scopus）和 PubMed。经过筛选，最终我们选择了 20 篇论文。确定了所有发表于 2000 年至 2021 年的相关研究。本研究结果表明，由于这些金属的生物累积特性，重金属暴露会导致肾脏和膀胱异常，并通过多种机制为这些器官中的恶性肿瘤提供基础。基于本研究的结果，由于包括铜、铁、锌和镍在内的少量重金属作为微量元素在酶和细胞生物反应中发挥着非常重要的作用，但暴露于砷、铅、钒和汞等一些重金属会对人们的健康造成不可逆转的影响，并导致各种疾病，包括肝癌、胰腺癌、前列腺癌、乳腺癌、肾癌和膀胱癌。肾脏、输尿管和膀胱是人体泌尿系统中最重要的器官。根据本研究的结果，该泌尿系统的职责是从血液中清除毒素、化学物质和重金属，平衡电解质，排出多余的液体，产生尿液并将其输送到膀胱。这种机制使肾脏和膀胱与这些毒素和重金属高度相关，这可能导致这两个重要器官出现各种疾病。根据研究结果，通过各种方式减少重金属暴露可以预防与该系统相关的许多疾病，并降低肾癌和膀胱癌的发病率。
