小巧而强大：葡萄糖稳态中的微外显子。
Small but mighty: microexons in glucose homeostasis.
机构信息
Department of Genetics, Stanford School of Medicine, Stanford, CA, USA.
Department of Genetics, Stanford School of Medicine, Stanford, CA, USA; Department of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford, CA, USA; Stanford Diabetes Research Center, Stanford School of Medicine, Stanford, CA, USA.
出版信息
Trends Genet. 2023 Jul;39(7):526-527. doi: 10.1016/j.tig.2023.04.003. Epub 2023 Apr 18.
Abstract
Many molecular mechanisms underlying blood glucose homeostasis remain elusive. Juan-Mateu et al. find that pancreatic islet cells utilize a regulatory program, originally identified in neurons, that involves alternative splicing of microexons in genes important for insulin secretion or diabetes risk.
摘要
许多血糖稳态的分子机制仍然难以捉摸。Juan-Mateu 等人发现，胰岛细胞利用了一种最初在神经元中发现的调节程序，该程序涉及对胰岛素分泌或糖尿病风险相关基因的微外显子的选择性剪接。
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