Parkin A, Robinson P J, Wiggins P A, Leveson S H, Salter M C, Matthews I F, Ware F M
Br J Radiol. 1986 May;59(701):493-7. doi: 10.1259/0007-1285-59-701-493.
A method for measuring blood flow below the knee during reactive hyperaemia induced by 3 min of arterial occlusion has been developed. Subjects are positioned with lower limbs within the field of view of a gamma camera and pneumatic cuffs are placed below the knees to isolate the blood and induce a hyperaemic response. The remaining blood pool is labelled with 99Tcm-labelled red cells. Blood flows have been derived from the initial gradients of time-activity curves and from equilibrium blood sampling. The technique has been validated using a tissue-equivalent leg phantom and peristaltic pump. The method has been applied to a small group of patients with peripheral vascular disease and to normal controls. The mean value (+/- SD) of limb perfusion for normal controls was found to be 16.4 +/- 3.0 ml/100 ml/min and for patients with intermittent claudication was 5.1 +/- 2.6 ml/100 ml/min. Flow measurements are found to correlate with clinical findings and with symptoms. Reproducibility (established by repeated measurements) is high. The method is well tolerated even by patients suffering from rest pain.
已开发出一种测量在3分钟动脉闭塞诱导的反应性充血期间膝下血流量的方法。受试者的下肢置于γ相机视野内，在膝盖下方放置气动袖带以隔离血液并诱导充血反应。剩余血池用99锝标记的红细胞标记。血流量通过时间-活性曲线的初始梯度和平衡血样分析得出。该技术已使用组织等效腿部模型和蠕动泵进行了验证。该方法已应用于一小群外周血管疾病患者和正常对照。发现正常对照的肢体灌注平均值（±标准差）为16.4±3.0 ml/100 ml/min，间歇性跛行患者为5.1±2.6 ml/100 ml/min。发现血流测量值与临床发现及症状相关。（通过重复测量确定的）可重复性很高。即使是患有静息痛的患者也能很好地耐受该方法。
