MacLennan F M, Foster M A, Smith F W, Crosher G A
Br J Radiol. 1986 Jun;59(702):553-60. doi: 10.1259/0007-1285-59-702-553.
An accurate, non-invasive means of measuring pulmonary water is desirable, for both clinical and research use. Nuclear magnetic resonance imaging is theoretically very suitable for this purpose. Nuclear magnetic resonance (NMR) spectroscopy was used to show that the water content of lung tissue could be predicted accurately from the intensity of signal resulting from a 90 degree saturation recovery sequence. The water contained in an image section may, therefore, be calculated by reference to a 100% water standard. Lung water was obtained by imaging the lung in continuous sections and summing the water contents of the component sections. The method performed well when applied to a sponge phantom, but underestimated by up to 30% in excised sheep lung. The total (vascular and extravascular) pulmonary water measured by NMR in six healthy volunteers was 292 g (SD 58 g) or 4.6 g/kg body weight, less than predicted by some other indirect methods and post-mortem values. A briefer examination comprising two axial sections at standardised levels was also devised. In 15 healthy volunteers the mean water content of a 1.6 cm-thick axial section through the right lung was 17.8 g at the sternal angle, and 23.3 g 5 cm caudally. In the left lung, the values were 16.4 g and 16.3 g, respectively.
无论是临床应用还是研究用途，都需要一种准确、无创的测量肺水的方法。核磁共振成像在理论上非常适合这一目的。核磁共振（NMR）光谱法被用于表明，肺组织的含水量可以根据90度饱和恢复序列产生的信号强度准确预测。因此，图像切片中所含的水可以通过参照100%水标准来计算。通过对肺进行连续切片成像并将各组成切片的含水量相加来获得肺水。该方法应用于海绵模型时效果良好，但在切除的羊肺中低估了高达30%。通过核磁共振测量的6名健康志愿者的总（血管内和血管外）肺水为292克（标准差58克）或4.6克/千克体重，低于其他一些间接方法和尸检值的预测结果。还设计了一种更简短的检查方法，包括在标准化层面进行两个轴向切片检查。在15名健康志愿者中，通过右肺的一个1.6厘米厚轴向切片在胸骨角处的平均含水量为17.8克，在其下方5厘米处为23.3克。在左肺中，相应的值分别为16.4克和16.3克。
