Siefkin A D, Nichols B G
Am Rev Respir Dis. 1986 Sep;134(3):509-12. doi: 10.1164/arrd.1986.134.3.509.
Three models of volume-dependent pulmonary edema were used in rabbits. Changes in lung water were measured by proton (1H) nuclear magnetic resonance spectroscopy (NMR) using a surface coil system, topical magnetic resonance. The anesthetized rabbits were ventilated with high frequency jet ventilation to minimize lung motion, and the surface coil was placed on the rabbit chest wall over the right lung. The rabbit preparation was placed in an Oxford Research Systems TMR-32 20-cm bore magnet. There was a close correlation (r greater than or equal to 0.90) between the gravimetrically determined lung wet to dry weight ratios and the percent change in the spectral areas as measured with 1H NMR, in all 3 experimental models.
在兔子身上使用了三种容量依赖性肺水肿模型。采用表面线圈系统（局部磁共振）通过质子（1H）核磁共振波谱法（NMR）测量肺水的变化。对麻醉后的兔子进行高频喷射通气以尽量减少肺部运动，将表面线圈置于右肺上方的兔子胸壁上。将兔子制备物放入牛津研究系统TMR - 32 20厘米孔径的磁体中。在所有3个实验模型中，通过重量法测定的肺湿重与干重之比与用1H NMR测量的光谱面积百分比变化之间存在密切相关性（r大于或等于0.90）。
