Wexler H R, Nicholson R L, Prato F S, Carey L S, Vinitski S, Reese L
Invest Radiol. 1985 Sep;20(6):583-90. doi: 10.1097/00004424-198509000-00010.
Pulmonary edema was produced in four anesthetized dogs by saline lavage. The animals were maintained by assisted ventilation with O2/halothane and examined by a nuclear magnetic resonance (NMR) 0.15T resistive-magnet imager. The distribution of edematous fluid was clearly observed. Image contrast increased with prolongation of the cycle time (TR). Tomographic maps of spin-lattice relaxation times (T1) of the lungs were calculated from the NMR images. Comparison of T1 values with gravimetric measurements of water content of lung samples showed significant correlation (r = .7, P less than .02, n = 12) suggesting a potential for in vivo lung water quantitation by NMR imaging. This in vivo correlation is qualitatively similar to the in vitro correlation. Accurate in vivo determinations of pulmonary T2 values may require respiratory gating.
通过盐水灌洗法在四只麻醉犬身上诱发肺水肿。这些动物通过氧气/氟烷辅助通气维持，并使用一台0.15T电阻磁体核磁共振（NMR）成像仪进行检查。清晰观察到了水肿液的分布。图像对比度随重复时间（TR）的延长而增加。根据NMR图像计算出肺部的自旋晶格弛豫时间（T1）断层图。将T1值与肺样本含水量的重量测量结果进行比较，显示出显著相关性（r = 0.7，P < 0.02，n = 12），这表明通过NMR成像进行体内肺水定量分析具有潜力。这种体内相关性在定性上与体外相关性相似。准确进行肺部T2值的体内测定可能需要呼吸门控。
