School of Science, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China; Centro de Química Estrutural, Institute of Molecular Sciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.
Department of Chemistry, Kurukshetra University Kurukshetra -136119, India.
Environ Int. 2023 May;175:107928. doi: 10.1016/j.envint.2023.107928. Epub 2023 Apr 11.
Pharmaceutical residues are the undecomposed remains from drugs used in the medical and food industries. Due to their potential adverse effects on human health and natural ecosystems, they are of increasing worldwide concern. The acute detection of pharmaceutical residues can give a rapid examination of their quantity and then prevent them from further contamination. Herein, this study summarizes and discusses the most recent porous covalent-organic frameworks (COFs) and metal-organic frameworks (MOFs) for the electrochemical detection of various pharmaceutical residues. The review first introduces a brief overview of drug toxicity and its effects on living organisms. Subsequently, different porous materials and drug detection techniques are discussed with materials' properties and applications. Then the development of COFs and MOFs has been addressed with their structural properties and sensing applications. Further, the stability, reusability, and sustainability of MOFs/COFs are reviewed and discussed. Besides, COFs and MOFs' detection limits, linear ranges, the role of functionalities, and immobilized nanoparticles are analyzed and discussed. Lastly, this review summarized and discussed the MOF@COF composite as sensors, the fabrication strategies to enhance detection potential, and the current challenges in this area.
药物残留是医药和食品工业中使用的药物未分解的残余物。由于它们对人类健康和自然生态系统可能产生的不利影响，药物残留受到了全世界越来越多的关注。药物残留的急性检测可以快速检查其数量，从而防止其进一步污染。本文总结和讨论了最近用于电化学检测各种药物残留的多孔共价有机骨架（COFs）和金属有机骨架（MOFs）。本文首先简要介绍了药物毒性及其对生物体的影响。随后，讨论了不同的多孔材料和药物检测技术，并介绍了材料的特性和应用。然后介绍了 COFs 和 MOFs 的发展，包括它们的结构特性和传感应用。此外，还对 MOFs/COFs 的稳定性、可重复性和可持续性进行了综述和讨论。此外，还分析和讨论了 COFs 和 MOFs 的检测限、线性范围、官能团的作用以及固定化纳米粒子的作用。最后，本文总结和讨论了作为传感器的 MOF@COF 复合材料、提高检测潜力的构建策略以及该领域目前的挑战。
