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工程化细胞膜包覆的催化剂作为多功能人工过氧化物酶体在生物医学中的应用。

Engineering Cell Membrane-Cloaked Catalysts as Multifaceted Artificial Peroxisomes for Biomedical Applications.

机构信息

Department of Ultrasound, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Med-X Center for Materials, Sichuan University, Chengdu, 610041, China.

Department of Ultrasound, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.

出版信息

Adv Sci (Weinh). 2023 Jun;10(17):e2206181. doi: 10.1002/advs.202206181. Epub 2023 Apr 25.

DOI:10.1002/advs.202206181
PMID:37096840
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10265064/
Abstract

Artificial peroxisomes (APEXs) or peroxisome mimics have caught a lot of attention in nanomedicine and biomaterial science in the last decade, which have great potential in clinically diagnosing and treating diseases. APEXs are typically constructed from a semipermeable membrane that encloses natural enzymes or enzyme-mimetic catalysts to perform peroxisome-/enzyme-mimetic activities. The recent rapid progress regarding their biocatalytic stability, adjustable activity, and surface functionality has significantly promoted APEXs systems in real-life applications. In addition, developing a facile and versatile system that can simulate multiple biocatalytic tasks is advantageous. Here, the recent advances in engineering cell membrane-cloaked catalysts as multifaceted APEXs for diverse biomedical applications are highlighted and commented. First, various catalysts with single or multiple enzyme activities have been introduced as cores of APEXs. Subsequently, the extraction and function of cell membranes that are used as the shell are summarized. After that, the applications of these APEXs are discussed in detail, such as cancer therapy, antioxidant, anti-inflammation, and neuron protection. Finally, the future perspectives and challenges of APEXs are proposed and outlined. This progress review is anticipated to provide new and unique insights into cell membrane-cloaked catalysts and to offer significant new inspiration for designing future artificial organelles.

摘要

人工过氧化物酶体 (APEXs) 或过氧化物酶模拟物在过去十年中引起了纳米医学和生物材料科学领域的广泛关注，它们在临床诊断和治疗疾病方面具有巨大的潜力。APEXs 通常由半透膜构建而成，其中包含天然酶或酶模拟催化剂，以发挥过氧化物酶/酶模拟活性。最近，其生物催化稳定性、可调活性和表面功能的快速发展显著推动了 APEXs 系统在实际应用中的发展。此外，开发一种能够模拟多种生物催化任务的简便多功能系统是有利的。在这里，重点介绍和评论了近年来工程细胞膜包裹催化剂作为多功能 APEXs 在多种生物医学应用中的进展。首先，介绍了具有单一或多种酶活性的各种催化剂作为 APEXs 的核心。随后，总结了用作外壳的细胞膜的提取和功能。之后，详细讨论了这些 APEXs 在癌症治疗、抗氧化、抗炎和神经元保护等方面的应用。最后，提出并概述了 APEXs 的未来展望和挑战。预计本综述将为细胞膜包裹催化剂提供新的独特见解，并为设计未来的人工细胞器提供重要的新灵感。

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