Camilleri M, Brown M L, Malagelada J R
Gastroenterology. 1986 Jul;91(1):94-9. doi: 10.1016/0016-5085(86)90444-0.
The mechanism of gastric stasis in disorders of gastrointestinal motility is largely unexplored. The region or regions of abnormal motility in 13 patients with a gastrointestinal motility disorder were characterized manometrically. Antral hypomotility was established in 6 patients and intestinal dysmotility in 7 others. One patient had both antral hypomotility and intestinal dysmotility. Gastric emptying of solids and liquids was quantitated scintigraphically; emptying data for solids were represented by a two-phase model (lag and emptying) and for liquids by a power exponential model. Antral hypomotility was associated with gastric stasis manifested by both a prolongation of the solid lag time [from 35 +/- 6 min for controls to 87 +/- 23 min (mean +/- SE), p less than 0.05] and slower emptying rates of solids (from a slope index of 29.9 +/- 2 for controls to 17.8 +/- 5, p less than 0.05) and liquids (from a kappa index of 3.6 +/- 0.6 for controls to 1.5 +/- 0.5, p less than 0.05). Intestinal dysmotility did not alter the solid lag time; however, it did decrease the slope of solid emptying from the stomach (from a slope index of 29.9 +/- 2 for controls to 13.5 +/- 3, p less than 0.05) and also prolonged emptying of liquids (from a kappa index of 3.6 +/- 0.3 for controls to 1.9 +/- 0.6, p less than 0.05). These data are consistent with the hypothesis that the gastric stasis in gut dysmotilities occurs because of impaired antral peristalsis due to antral hypomotility or increased resistance to flow into the small bowel due to intestinal dysmotility.
胃肠动力障碍中胃潴留的机制在很大程度上尚未得到充分研究。对13例胃肠动力障碍患者的异常动力区域进行了测压表征。6例患者存在胃窦部动力不足，7例存在肠道动力障碍。1例患者同时存在胃窦部动力不足和肠道动力障碍。通过闪烁扫描法定量测定固体和液体的胃排空情况；固体排空数据用两相模型（延迟和排空）表示，液体排空数据用幂指数模型表示。胃窦部动力不足与胃潴留相关，表现为固体延迟时间延长[从对照组的35±6分钟延长至87±23分钟（平均值±标准误），p<0.05]，固体排空速率减慢（从对照组的斜率指数29.9±2降至17.8±5，p<0.05）以及液体排空减慢（从对照组的kappa指数3.6±0.6降至1.5±0.5，p<0.05）。肠道动力障碍未改变固体延迟时间；然而，它确实降低了胃内固体排空的斜率（从对照组的斜率指数29.9±2降至13.5±3，p<0.05），并延长了液体排空时间（从对照组的kappa指数3.6±0.3降至1.9±0.6，p<0.05）。这些数据与以下假设一致，即肠道动力障碍中的胃潴留是由于胃窦部动力不足导致胃窦蠕动受损，或由于肠道动力障碍导致流入小肠的阻力增加所致。
