MRC Laboratory of Molecular Biology, Structural Studies Division, Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK.
MRC Laboratory of Molecular Biology, Structural Studies Division, Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK.
Curr Opin Struct Biol. 2023 Jun;80:102598. doi: 10.1016/j.sbi.2023.102598. Epub 2023 Apr 25.
Structural maintenance of chromosomes (SMC) complexes guard and organize the three-dimensional structure of chromosomal DNA across the tree of life. Many SMC functions can be explained by an inherent motor activity that extrudes large DNA loops while the complexes move along their substrate. Here, we review recent structural insights into the architecture and conservation of these molecular machines, their interaction with DNA, and the conformational changes that are linked to their ATP hydrolysis cycle.
结构维持染色体 (SMC) 复合物保护和组织跨越生命之树的染色体 DNA 的三维结构。许多 SMC 功能可以通过固有马达活性来解释，该活性在复合物沿着其底物移动的同时挤出大的 DNA 环。在这里，我们回顾了这些分子机器的结构见解的最新进展，包括它们的结构和保守性、与 DNA 的相互作用以及与它们的 ATP 水解循环相关的构象变化。
