Tomanić Dragana, Božić Dragana D, Kladar Nebojša, Samardžija Marko, Apić Jelena, Baljak Jovan, Kovačević Zorana
Department of Veterinary Medicine, Faculty of Agriculture, University of Novi Sad, Trg Dositeja Obradovica 8, 21000 Novi Sad, Serbia.
Department of Microbiology and Immunology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia.
Antibiotics (Basel). 2024 Jun 22;13(7):575. doi: 10.3390/antibiotics13070575.
Bovine mastitis, as a significant and prevalent health problem in dairy herds, is primarily attributed to bacterial infections. Yeasts, although considered relatively rare causative agents, have also been associated with mastitis in dairy cattle. Current mastitis treatment predominantly relies on antibiotics, with limited emphasis on antifungal treatment. However, mycotic mastitis is challenging to treat, since these fungi are often resistant to antibiotics and may even utilize them for energy. In the current research, the in vivo antimicrobial activity of the essential oil-based formulation (Phyto-Bomat), as a possible alternative mastitis treatment associated with yeasts, was studied. This study involved a total of 68 animals from two dairy farms with diagnosed mastitis, and three treatment groups were established: conventional antibiotic treatment, Phyto-Bomat treatment, and the combination of both. The findings suggest significant variations in the presence of Candida samples based on the treatment administered, and the most significant difference was noted in cows treated with the combination (Phyto-Bomat and antibiotics). Yet, it is important to note that the results reveal that, regardless of the treatment type, there are statistically significant differences in the presence of Candida samples across the examined time points. These results aim to provide valuable insights into the potential of EOs as an alternative therapy in bovine mastitis, specifically targeting yeasts. Such findings could offer new strategies in the mycotic mastitis control and reducing the occurrence of secondary infections following antibiotic treatment.
牛乳腺炎是奶牛群中一个严重且普遍的健康问题，主要由细菌感染引起。酵母菌虽然被认为是相对罕见的致病因素，但也与奶牛乳腺炎有关。目前乳腺炎的治疗主要依赖抗生素，对抗真菌治疗的重视有限。然而，霉菌性乳腺炎治疗具有挑战性，因为这些真菌往往对抗生素耐药，甚至可能利用抗生素获取能量。在当前的研究中，研究了基于精油的制剂（植物炸弹）作为与酵母菌相关的乳腺炎可能替代治疗方法的体内抗菌活性。这项研究共涉及来自两个诊断出乳腺炎的奶牛场的68头动物，并设立了三个治疗组：传统抗生素治疗、植物炸弹治疗以及两者联合治疗。研究结果表明，根据所给予的治疗，念珠菌样本的存在有显著差异，在联合治疗（植物炸弹和抗生素）的奶牛中差异最为显著。然而，需要注意的是，结果显示，无论治疗类型如何，在所检查的时间点上念珠菌样本的存在在统计学上都有显著差异。这些结果旨在为精油作为牛乳腺炎替代疗法的潜力提供有价值的见解，特别是针对酵母菌。这些发现可为霉菌性乳腺炎的控制以及减少抗生素治疗后二次感染的发生提供新策略。
