Zhang Yuting, Pan Junjie, Liu Yanan, Zhang Xin, Cheng Kejun
Department of Food Science and Engineering, Ningbo University, Ningbo 315211, China.
Chemical Biology Center, Lishui Institute of Agriculture and Forestry Sciences, Lishui 323000, China.
Foods. 2023 Apr 18;12(8):1682. doi: 10.3390/foods12081682.
More and more evidence has supported the interaction between circadian rhythms and intestinal microbes, which provides new insights into how dietary nutrition can improve host health. Our research showed that Hance var. Cheng flavonoids (FCF) ameliorated the pathological damage of colon and abnormal intestinal microflora structure in mice with circadian clock disorder and improved their exploration and memory behaviors. Mechanism studies have shown that FCF is involved in regulating metabolic pathways and related metabolites, regulating the expression of related tight junction proteins in the colon and the levels of Aβ and inflammatory factors in the hippocampus. Further analysis found that these metabolites showed a certain correlation with intestinal flora and played a certain role in alleviating intestinal physiological damage and cognitive decline.
越来越多的证据支持昼夜节律与肠道微生物之间的相互作用，这为饮食营养如何改善宿主健康提供了新的见解。我们的研究表明，山木通黄酮（FCF）改善了昼夜节律紊乱小鼠的结肠病理损伤和肠道微生物群结构异常，并改善了它们的探索和记忆行为。机制研究表明，FCF参与调节代谢途径和相关代谢产物，调节结肠中相关紧密连接蛋白的表达以及海马体中Aβ和炎症因子的水平。进一步分析发现，这些代谢产物与肠道菌群呈现出一定的相关性，并在减轻肠道生理损伤和认知衰退方面发挥了一定作用。
