Salazar Marcano David E, Savić Nada D, Abdelhameed Shorok A M, de Azambuja Francisco, Parac-Vogt Tatjana N
Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium.
JACS Au. 2023 Feb 13;3(4):978-990. doi: 10.1021/jacsau.3c00011. eCollection 2023 Apr 24.
The latest advances in the study of the reactivity of metal-oxo clusters toward proteins showcase how fundamental insights obtained so far open new opportunities in biotechnology and medicine. In this Perspective, these studies are discussed through the lens of the reactivity of a family of soluble anionic metal-oxo nanoclusters known as polyoxometalates (POMs). POMs act as catalysts in a wide range of reactions with several different types of biomolecules and have promising therapeutic applications due to their antiviral, antibacterial, and antitumor activities. However, the lack of a detailed understanding of the mechanisms behind biochemically relevant reactions-particularly with complex biological systems such as proteins-still hinders further developments. Hence, in this Perspective, special attention is given to reactions of POMs with peptides and proteins showcasing a molecular-level understanding of the reaction mechanism. In doing so, we aim to highlight both existing limitations and promising directions of future research on the reactivity of metal-oxo clusters toward proteins and beyond.
金属氧簇与蛋白质反应性研究的最新进展展示了迄今为止所获得的基础见解如何为生物技术和医学带来新机遇。在这篇视角文章中，将通过一类称为多金属氧酸盐（POMs）的可溶性阴离子金属氧纳米簇的反应性来探讨这些研究。POMs在与几种不同类型生物分子的广泛反应中充当催化剂，并且由于其抗病毒、抗菌和抗肿瘤活性而具有广阔的治疗应用前景。然而，对生物化学相关反应背后机制的详细理解不足，尤其是与蛋白质等复杂生物系统的反应，仍然阻碍着进一步的发展。因此，在这篇视角文章中，特别关注POMs与肽和蛋白质的反应，以展示对反应机制的分子水平理解。通过这样做，我们旨在突出金属氧簇与蛋白质及其他物质反应性研究中现有的局限性和未来研究的有前景方向。
