Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou 350108, China.
School of Chemical and Biological Engineering, Qilu Institute of Technology, Jinan 250200, P. R. China.
Nano Lett. 2023 May 10;23(9):3929-3938. doi: 10.1021/acs.nanolett.3c00632. Epub 2023 Apr 27.
Manufacturing heteronanostructures with specific physicochemical characteristics and tightly controllable designs is very appealing. Herein, we reported NIR-II light-driven dual plasmonic (AuNR-SiO-CuS) antimicrobial nanomotors with an intended Janus configuration through the overgrowth of copper-rich CuS nanocrystals at only one high-curvature site of Au nanorods (Au NRs). These nanomotors were applied for photoacoustic imaging (PAI)-guided synergistic photothermal and photocatalytic treatment of bacterial infections. Both the photothermal performance and photocatalytic activity of the nanomotors are dramatically improved owing to the strong plasmon coupling between Au NRs and the CuS component and enhanced energy transfer. The motion behavior of nanomotors promotes transdermal penetration and enhances the matter-bacteria interaction. More importantly, the directional navigation and synergistic antimicrobial activity of the nanomotors could be synchronously driven by NIR-II light. The marriage of active motion and enhanced antibacterial activity resulted in the expected good antibacterial effects in an abscess infection mouse model.
制造具有特定物理化学特性和可严格控制设计的异质纳米结构非常吸引人。在此，我们通过在金纳米棒（AuNRs）的一个高曲率位点上仅生长富含铜的 CuS 纳米晶体，报道了具有预期的双面（AuNR-SiO-CuS）抗菌纳米马达，该纳米马达在近红外二区（NIR-II）光驱动下具有双重等离子体特性。这些纳米马达被应用于光声成像（PAI）引导的协同光热和光催化治疗细菌感染。由于 Au NRs 和 CuS 组件之间的强等离子体耦合以及增强的能量转移，纳米马达的光热性能和光催化活性都得到了显著提高。纳米马达的运动行为促进了透皮渗透，并增强了物质-细菌的相互作用。更重要的是，纳米马达的定向导航和协同抗菌活性可以通过近红外二区（NIR-II）光同步驱动。主动运动和增强的抗菌活性的结合导致在脓肿感染小鼠模型中产生了预期的良好抗菌效果。
Zotero 插件