血清尿酸水平在酒精依赖患者认知功能障碍发生中的临床价值
Clinical Values of Serum Uric Acid Levels in the Occurrence of Cognitive Impairment in Alcohol-Dependent Patients.
作者信息
Bai Jinglin, Huang Xiuqin, Ma Zhanping, Ji Bowen, Zheng Xiangyang
机构信息
Department of Psychiatry, Hengshui Seventh People's Hospital, Hengshui, China.
出版信息
Alpha Psychiatry. 2023 Mar 1;24(2):43-48. doi: 10.5152/alphapsychiatry.2023.221065. eCollection 2023 Mar.
OBJECTIVE
Studies have confirmed that uric acid is involved in the regulation of cognitive function. This study aimed to investigate the expression of serum uric acid in alcohol-dependent patients and evaluate its clinical diagnostic value for cognitive impairment.
METHODS
Blood sample was collected for assessment of serum uric acid levels. Montreal Cognitive Assessment Scale scores were obtained to assess cognitive function. Anxiety and depression scores on the Symptom Check List 90 scale were used to assess mental health status. The alcohol-dependent patients were divided into non-cognitive impairment and cognitive impairment groups according to Montreal Cognitive Assessment Scale score, and the serum uric acid levels of these groups were analyzed. The receiver operating characteristic curve evaluated the diagnostic value of serum uric acid in cognitive impairment patients. Pearson correlation coefficient evaluated the correlation between uric acid and Montreal Cognitive Assessment Scale score, anxiety score, and depression score. Multivariate logistic regression analyzed the association between each index and cognitive impairment in patients.
RESULTS
Serum uric acid was higher in patients than in controls ( < .001). Uric acid was significantly increased in cognitive impairment patients than in non-cognitive impairment patients ( < .001). Serum uric acid has certain diagnostic value in patients with cognitive impairment. Anxiety score and depression score were positively correlated with uric acid level, while Montreal Cognitive Assessment Scale score was negatively correlated with uric acid. Additionally, serum uric acid, Montreal Cognitive Assessment Scale score, and anxiety and depression scores were the risk factors for cognitive impairment in patients ( < .05).
CONCLUSION
The abnormal expression of uric acid has a high diagnostic accuracy for distinguishing cognitive impairment from non-cognitive impairment.
目的
研究已证实尿酸参与认知功能的调节。本研究旨在调查酒精依赖患者血清尿酸的表达情况，并评估其对认知障碍的临床诊断价值。
方法
采集血样以评估血清尿酸水平。采用蒙特利尔认知评估量表评分来评估认知功能。使用症状自评量表90项症状清单上的焦虑和抑郁评分来评估心理健康状况。根据蒙特利尔认知评估量表评分将酒精依赖患者分为非认知障碍组和认知障碍组，并分析这两组的血清尿酸水平。采用受试者工作特征曲线评估血清尿酸在认知障碍患者中的诊断价值。皮尔逊相关系数评估尿酸与蒙特利尔认知评估量表评分、焦虑评分和抑郁评分之间的相关性。多因素逻辑回归分析各指标与患者认知障碍之间的关联。
结果
患者血清尿酸水平高于对照组（<0.001）。认知障碍患者的尿酸水平显著高于非认知障碍患者（<0.001）。血清尿酸在认知障碍患者中具有一定的诊断价值。焦虑评分和抑郁评分与尿酸水平呈正相关，而蒙特利尔认知评估量表评分与尿酸呈负相关。此外，血清尿酸、蒙特利尔认知评估量表评分以及焦虑和抑郁评分是患者认知障碍的危险因素（<0.05）。
结论
尿酸的异常表达在区分认知障碍与非认知障碍方面具有较高的诊断准确性。
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