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通过乳酸调节对宫颈癌免疫反应进行分析揭示了驱动临床结果的关键特征。

Profiling of immune responses by lactate modulation in cervical cancer reveals key features driving clinical outcome.

作者信息

Yang Xiaoyue, Zhang Wenjing, Zhu Weipei

机构信息

Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow University, Sanxiang Road 1055, Suzhou 215000,Jiangsu Province, China.

School of Medicine, Jiangsu University, No. 301 Xuefu Road, Jingkou District, Zhenjiang City 212001, Jiangsu Province, China.

出版信息

Heliyon. 2023 Mar 25;9(4):e14896. doi: 10.1016/j.heliyon.2023.e14896. eCollection 2023 Apr.

DOI:10.1016/j.heliyon.2023.e14896
PMID:37151676
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10161385/
Abstract

Cervical cancer is still an important problem perplexing health management in developing countries. Previous studies have shown that cervical cancer cells show markers of aerobic glycolysis, suggesting that these tumors may secrete lactic acid. Through the biological characterization of lactate gene in tumor and its relationship with immune cells in tumor microenvironment, a lactate scoring system capable of evaluating cancer prognosis was constructed to explore the molecular mechanism of lactate metabolism disorder affecting prognosis. 29 hub genes in this study were differentially expressed in cervical cancer, including 24 genes related to lactate metabolism, LDHA in Lactate dehydrogenase (LDH) group, SLC16A3 in Monocarboxylate transporters (MCT) group and three Histone lactation modification related genes (EP300, ACAT1, ACACA). More importantly, we found that from an epigenetic point of view, histone lactation plays an important role in the pathogenesis and prognosis of cervical cancer. Mainly affect the prognosis of the disease through changes in the infiltration of plasmacytoid Dendritic Cell (pDC) and Central Memory T cell (Tcm) in the tumor immune microenvironment. Lactate inhibition may be a useful tool for anticancer therapy.

摘要

宫颈癌仍是困扰发展中国家卫生管理的一个重要问题。以往研究表明，宫颈癌细胞表现出有氧糖酵解的标志物，提示这些肿瘤可能分泌乳酸。通过对肿瘤中乳酸基因的生物学特性及其与肿瘤微环境中免疫细胞的关系进行研究，构建了一种能够评估癌症预后的乳酸评分系统，以探讨乳酸代谢紊乱影响预后的分子机制。本研究中的29个枢纽基因在宫颈癌中差异表达，包括24个与乳酸代谢相关的基因、乳酸脱氢酶（LDH）组中的LDHA、单羧酸转运蛋白（MCT）组中的SLC16A3以及3个与组蛋白乳酸修饰相关的基因（EP300、ACAT1、ACACA）。更重要的是，我们从表观遗传学角度发现，组蛋白乳酸化在宫颈癌的发病机制和预后中起重要作用。主要通过改变肿瘤免疫微环境中浆细胞样树突状细胞（pDC）和中枢记忆T细胞（Tcm）的浸润来影响疾病的预后。乳酸抑制可能是一种有用的抗癌治疗工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ff/10161385/75ab222aa907/gr12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ff/10161385/f639c878a070/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ff/10161385/01d48b98bf08/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ff/10161385/5041570a0ca1/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ff/10161385/e6c76b080296/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ff/10161385/2569bbb6ac84/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ff/10161385/874de48ff304/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ff/10161385/ad85c20070e6/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ff/10161385/c7eff4cb0bca/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ff/10161385/55666335c6ca/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ff/10161385/7beef66ca2dc/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ff/10161385/8481e98ae028/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ff/10161385/75ab222aa907/gr12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ff/10161385/f639c878a070/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ff/10161385/01d48b98bf08/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ff/10161385/5041570a0ca1/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ff/10161385/e6c76b080296/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ff/10161385/2569bbb6ac84/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ff/10161385/874de48ff304/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ff/10161385/ad85c20070e6/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ff/10161385/c7eff4cb0bca/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ff/10161385/55666335c6ca/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ff/10161385/7beef66ca2dc/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ff/10161385/8481e98ae028/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ff/10161385/75ab222aa907/gr12.jpg

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2
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Nat Rev Cancer. 2021 Mar;21(3):162-180. doi: 10.1038/s41568-020-00320-2. Epub 2021 Jan 18.
3
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Front Immunol. 2025 May 12;16:1581582. doi: 10.3389/fimmu.2025.1581582. eCollection 2025.
4
Bioinformatics Based Drug Repurposing Approach for Breast and Gynecological Cancers: Genes Address Common Hub Genes and Drugs.基于生物信息学的乳腺癌和妇科癌症药物再利用方法：基因定位共同枢纽基因和药物。
Eur J Breast Health. 2025 Jan 1;21(1):63-73. doi: 10.4274/ejbh.galenos.2024.2024-11-2.
5
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Front Immunol. 2024 Nov 6;15:1467052. doi: 10.3389/fimmu.2024.1467052. eCollection 2024.
6
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Bioprocess Biosyst Eng. 2024 Aug;47(8):1393-1407. doi: 10.1007/s00449-024-03047-8. Epub 2024 Jun 28.
7
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Nat Rev Immunol. 2021 Mar;21(3):151-161. doi: 10.1038/s41577-020-0406-2. Epub 2020 Aug 24.
4
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