Department of International Physical Examination and Health Center, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Department of Hygiene Microbiology, School of Public Health, Harbin Medical University, Harbin, China.
Front Endocrinol (Lausanne). 2023 Apr 21;14:1163682. doi: 10.3389/fendo.2023.1163682. eCollection 2023.
Obesity measurement indexes have certain screening value for metabolic diseases. To investigate associations between metabolic associated fatty liver disease (MAFLD) and obesity measurement indexes, including traditional indexes (BMI, WC, WHtR) and new indexes (ABSI, BRI, VAI, LAP), and assess their screening ability.
12,658 subjects aged 18-75 at the Health Center of a Class III Grade A Hospital were included, who were divided into MAFLD and non-MAFLD groups. Spearman's rank correlation was used to study the correlation between MAFLD and obesity measurement indexes. Receiver operating characteristic (ROC) curves were used to calculate the area under the curve (AUC) to evaluate their screening accuracy.
MAFLD had strong correlation with traditional BMI and new index LAP. ROC analysis showed that BMI had the highest AUC (0.89), followed by LAP (0.87). Stratification by BMI, LAP had the highest AUC (0.90) for MAFLD in population without obesity (BMI< 23kg/m), and its optimal cutoff value was 20.75, with a sensitivity and specificity of 85.9% and 79.0%, respectively.
We proposed a two-step screening strategy for MAFLD, combining BMI and LAP, and defined a high-risk population for MAFLD as follows: 1) BMI ≥ 23 kg/m; and 2) BMI< 23 kg/m and LAP ≥ 20.75.
肥胖测量指标对代谢性疾病具有一定的筛查价值。本研究旨在探讨代谢相关脂肪性肝病（MAFLD）与肥胖测量指标（包括传统指标 BMI、WC、WHtR 和新指标 ABSI、BRI、VAI、LAP）之间的关系，并评估其筛查能力。
本研究纳入了一家三级甲等医院健康中心 18-75 岁的 12658 名受试者，将其分为 MAFLD 组和非 MAFLD 组。采用 Spearman 秩相关分析 MAFLD 与肥胖测量指标的相关性。采用受试者工作特征（ROC）曲线计算曲线下面积（AUC）以评估其筛查准确性。
MAFLD 与传统 BMI 和新指标 LAP 具有较强的相关性。ROC 分析显示，BMI 的 AUC 最高（0.89），其次是 LAP（0.87）。在 BMI<23kg/m²的非肥胖人群中，BMI 和 LAP 分层后，LAP 对 MAFLD 的 AUC 最高（0.90），其最佳截断值为 20.75，灵敏度和特异度分别为 85.9%和 79.0%。
本研究提出了一种 MAFLD 的两步筛查策略，结合 BMI 和 LAP，将 MAFLD 的高危人群定义为：1）BMI≥23kg/m²；2）BMI<23kg/m²且 LAP≥20.75。
