H. Lee Moffit Cancer Center and Research Institute.
University of South Florida.
Oncol Nurs Forum. 2023 Apr 21;50(3):299-312. doi: 10.1188/23.ONF.299-312.
To conduct an integrative review of studies to identify disparities in quality of life (QOL), symptoms, and symptom burden between men and women diagnosed with hematologic malignancies.
SAMPLE & SETTING: 11 studies comprising 13,546 participants aged 18 years or older were included in the analysis. Studies were original peer-reviewed research published in English between January 2005 and December 2020.
METHODS & VARIABLES: A literature search was performed using keywords associated with health-related QOL, hematologic malignancy, and sex/gender differences. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were followed to identify relevant studies. Data were extracted for sex differences in QOL, symptoms, and symptom burden. All studies were appraised for quality and level of evidence.
Women have worse physical health and function, more pain, and higher symptom burden compared with men.
Healthcare providers need to understand the impact of sex-based differences on QOL, symptoms, and symptom burden to provide optimal, personalized care.
对研究进行综合回顾，以确定诊断为血液恶性肿瘤的男性和女性在生活质量（QOL）、症状和症状负担方面的差异。
纳入分析的 11 项研究包括 13546 名年龄在 18 岁或以上的参与者。这些研究是 2005 年 1 月至 2020 年 12 月期间以英文发表的原创同行评审研究。
使用与健康相关的 QOL、血液恶性肿瘤和性别/性别差异相关的关键词进行文献检索。遵循 PRISMA（系统评价和荟萃分析的首选报告项目）指南确定相关研究。提取 QOL、症状和症状负担方面的性别差异数据。对所有研究进行质量和证据水平评估。
与男性相比，女性的身体健康和功能更差，疼痛更多，症状负担更高。
医疗保健提供者需要了解基于性别的差异对 QOL、症状和症状负担的影响，以便提供最佳的个性化护理。
