United BioSource Corporation, 430 Bedford Street, Suite 300, Lexington, MA, 02420, USA,
Support Care Cancer. 2013 Oct;21(10):2853-60. doi: 10.1007/s00520-013-1854-z. Epub 2013 Jun 8.
This analysis examined associations between gender and health-related quality of life (HRQOL) in patients with B-cell chronic lymphocytic leukemia (CLL) as they initiate therapy for CLL outside the clinical trial setting.
Baseline data were collected as part of Connect® CLL Registry, a prospective observational study initiated in community, academic, and government centers. Patient demographics and clinical characteristics were provided by clinicians. Patients reported HRQOL using the Brief Fatigue Inventory (BFI), EQ-5D, and Functional Assessment of Cancer Therapy-Leukemia (FACT-Leu). Mean scores were analyzed, with statistical significance of differences determined by ANOVA. Multivariate analysis also considered age and line of therapy.
Baseline HRQOL data were available for 1,140 patients: 710 (62 %) men and 430 (38 %) women from 161 centers. Patients were predominantly white (89 %) with mean age 69 ± 11 years. Women reported significantly worse global fatigue (P <0.0001), fatigue severity (P <0.0001), and fatigue-related interference (P = 0.0005) versus men (BFI). Pain/discomfort (P = 0.0077), usual activities (P = 0.0015), and anxiety/depression (P = 0.0117) were significantly worse in women than in men (EQ-5D). With women reporting a better social/family score (P = 0.0238) and men reporting a better physical score (P = 0.0002), the mean FACT-G total score did not differ by gender. However, the mean FACT-Leu total score was better among men versus women (P = 0.0223), primarily because the mean leukemia subscale score was significantly better among men (P <0.0001). Multivariate analysis qualitatively confirmed these findings.
Connect® CLL Registry results indicate that significant differences exist in certain HRQOL domains, as women reported greater levels of fatigue and worse functioning in physical domains.
本分析研究了在临床试验环境之外开始治疗 B 细胞慢性淋巴细胞白血病 (CLL) 的患者中，性别与健康相关生活质量 (HRQOL) 之间的关联。
作为 Connect®CLL 登记处的一部分，收集了基线数据，这是一项在社区、学术和政府中心启动的前瞻性观察性研究。患者的人口统计学和临床特征由临床医生提供。患者使用简要疲劳量表 (BFI)、EQ-5D 和癌症治疗白血病功能评估 (FACT-Leu) 报告 HRQOL。分析了平均评分，通过方差分析确定差异的统计学意义。多变量分析还考虑了年龄和治疗线。
161 个中心的 1140 名患者提供了基线 HRQOL 数据：710 名（62%）男性和 430 名（38%）女性。患者主要为白人（89%），平均年龄 69±11 岁。与男性相比，女性报告的总体疲劳（P<0.0001）、疲劳严重程度（P<0.0001）和疲劳相关干扰（P=0.0005）明显更差（BFI）。女性的疼痛/不适（P=0.0077）、日常活动（P=0.0015）和焦虑/抑郁（P=0.0117）明显差于男性（EQ-5D）。女性报告社会/家庭评分更好（P=0.0238），男性报告身体评分更好（P=0.0002），因此，性别之间的 FACT-G 总分无差异。然而，男性的 FACT-Leu 总分优于女性（P=0.0223），主要是因为男性的白血病亚量表评分明显更好（P<0.0001）。多变量分析定性证实了这些发现。
Connect®CLL 登记处的结果表明，在某些 HRQOL 领域存在显著差异，因为女性报告疲劳程度更高，身体功能领域的功能更差。
