Kesharwani Anukriti, Dighe Onkar R, Lamture Yashwant
Department of General Surgery, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Cureus. 2023 Apr 6;15(4):e37205. doi: 10.7759/cureus.37205. eCollection 2023 Apr.
Gastric cancer (GC) is one of the leading causes of cancer-related deaths globally. Gastritis caused by is a potent cause of gastrointestinal malignancies. The majority of all humans on the planet have invasion in their stomachs, yet only a few diseased people develop GC. The human gastrointestinal system contains a broad population of microorganisms in addition to heterogeneity has been studied because not all diseases result in cancer. Individuals in the adult age group account for the bulk of gastric carcinoma cases. has various strains, which is beneficial for its survival in host cell epithelium for a longer duration of time. Along with , oral microbes have a major role in the pathogenicity of gastric carcinoma. The complex ecology of oral microbiota helps to defend against infections, preserve homeostasis, and regulate the immune system. In contrast, oral microbiota is involved in various mechanisms like anti-apoptotic activity, suppression of the immune system of the host, and initiation of chronic inflammation. These oral microbes are also responsible for the development of mutations. Interactions between the host immune system and bacteria promote the progression of cancer. For this review, various research articles were studied, and information was collected using databases like PubMed and Google Scholar. This review emphasizes on the role of in gastric carcinoma, its pathogenesis the role of various virulence factors and risk factors related to it, the role of oral microbiota in gastric carcinoma pathogenesis, diagnostic modalities, treatment options, and preventive measures for gastric carcinoma.
胃癌（GC）是全球癌症相关死亡的主要原因之一。由幽门螺杆菌引起的胃炎是胃肠道恶性肿瘤的一个重要病因。地球上大多数人胃部都有幽门螺杆菌感染，但只有少数患病者会发展为胃癌。人类胃肠道系统除了幽门螺杆菌外还包含大量微生物，由于并非所有幽门螺杆菌感染都会导致癌症，因此其异质性已得到研究。成年年龄组的个体占胃癌病例的大部分。幽门螺杆菌有多种菌株，这有利于其在宿主细胞上皮中存活更长时间。除了幽门螺杆菌外，口腔微生物在胃癌的致病性中也起主要作用。口腔微生物群的复杂生态有助于抵御感染、维持体内平衡和调节免疫系统。相比之下，口腔微生物群参与多种机制，如抗凋亡活性、抑制宿主免疫系统和引发慢性炎症。这些口腔微生物也与突变的发生有关。宿主免疫系统与细菌之间的相互作用促进了癌症的进展。在本次综述中，研究了各种研究文章，并使用PubMed和谷歌学术等数据库收集了信息。本综述强调了幽门螺杆菌在胃癌中的作用、其发病机制、各种毒力因子和相关危险因素的作用、口腔微生物群在胃癌发病机制中的作用、诊断方法、治疗选择以及胃癌的预防措施。
