Eggers Maren, Jungke Peggy, Wolkinger Volker, Bauer Rudolf, Kessler Uwe, Frank Bruno
Virologie, Labor Prof. Dr. G. Enders MVZ GbR, Stuttgart, Germany.
Technische Universität Dresden, Medical Faculty Carl Gustav Carus, Dresden, Germany.
Phytother Res. 2022 May;36(5):2109-2115. doi: 10.1002/ptr.7431. Epub 2022 Mar 1.
Respiratory viruses pose a significant threat to global health. They initially infect the naso- and oropharyngeal regions, where they amplify, cause symptoms, and may also be transmitted to new hosts. Preventing initial infection or reducing viral loads upon infection might soothe symptoms, prevent dissemination into the lower airways, or transmission to the next individual. Several natural products have well-described direct antiviral activity or may ameliorate symptoms of respiratory infections. We thus analyzed the potential of plant-derived products to inactivate respiratory viral pathogens and determined the antiviral activity of black chokeberry (Aronia melanocarpae [Michx.] Elliott), elderberry (Sambucus nigra L.), and pomegranate (Punica granatum L.) juice, as well as green tea (Camellia sinensis [L.] Kuntze) on the infectivity of the surrogate-modified vaccinia virus Ankara, and the respiratory viruses severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza A virus (IAV), and adenovirus Type 5. Black chokeberry and pomegranate juice, and green tea reduced SARS-CoV-2 and IAV titers by ≥80% or ≥99%. This suggests that oral rinsing with these products may reduce viral loads in the oral cavity which might prevent viral transmission.
呼吸道病毒对全球健康构成重大威胁。它们最初感染鼻咽和口咽区域，在这些部位增殖、引发症状，还可能传播给新宿主。预防初始感染或在感染后降低病毒载量可能会缓解症状，防止病毒扩散至下呼吸道，或避免传播给下一个个体。几种天然产物具有明确的直接抗病毒活性，或可改善呼吸道感染症状。因此，我们分析了植物源产品灭活呼吸道病毒病原体的潜力，并测定了黑果腺肋花楸（Aronia melanocarpae [Michx.] Elliott）、接骨木果（Sambucus nigra L.）、石榴（Punica granatum L.）汁以及绿茶（Camellia sinensis [L.] Kuntze）对替代病毒——改良安卡拉痘苗病毒，以及呼吸道病毒严重急性呼吸综合征冠状病毒2（SARS-CoV-2）、甲型流感病毒（IAV）和5型腺病毒感染性的影响。黑果腺肋花楸汁、石榴汁和绿茶使SARS-CoV-2和IAV滴度降低≥80%或≥99%。这表明用这些产品进行口腔冲洗可能会降低口腔中的病毒载量，从而预防病毒传播。
