Madar Z
Acta Diabetol Lat. 1986 Jan-Mar;23(1):35-42. doi: 10.1007/BF02581352.
This report describes the effects of four anesthetic agents on glucose metabolism in rats. Ketamine and nubain drastically increased plasma glucose levels in normal rats. They also caused a high death rate as compared to nembutal and seconal and, therefore, were not useful for studies of glucose kinetics. Although both nembutal and seconal had a moderate effect on glucose metabolism, seconal was preferred for epinephrine studies. As this agent displayed a moderate effect on glucose kinetics, it was also deemed suitable for use in the studies of glucose kinetics in diabetic rat models. This study indicates that glucose and probably fat metabolism under anesthesia require considerable further research.
本报告描述了四种麻醉剂对大鼠葡萄糖代谢的影响。氯胺酮和纳布啡显著提高了正常大鼠的血糖水平。与戊巴比妥和速可眠相比，它们还导致了较高的死亡率，因此，不适用于葡萄糖动力学研究。尽管戊巴比妥和速可眠对葡萄糖代谢都有中度影响，但在肾上腺素研究中首选速可眠。由于该药物对葡萄糖动力学有中度影响，它也被认为适用于糖尿病大鼠模型的葡萄糖动力学研究。本研究表明，麻醉状态下的葡萄糖以及可能的脂肪代谢需要进一步深入研究。
