Rawson Timothy M, Antcliffe David B, Wilson Richard C, Abdolrasouli Alireza, Moore Luke S P
Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Hammersmith Hospital, London, UK.
Centre for Antimicrobial Optimisation, Imperial College London, Imperial College London, London, UK.
Infect Drug Resist. 2023 May 4;16:2709-2726. doi: 10.2147/IDR.S390946. eCollection 2023.
Bacterial and fungal infections are common issues for patients in the intensive care unit (ICU). Large, multinational point prevalence surveys have identified that up to 50% of ICU patients have a diagnosis of bacterial or fungal infection at any one time. Infection in the ICU is associated with its own challenges. Causative organisms often harbour intrinsic and acquired mechanisms of drug-resistance, making empiric and targeted antimicrobial selection challenging. Infection in the ICU is associated with worse clinical outcomes for patients. We review the epidemiology of bacterial and fungal infection in the ICU. We discuss risk factors for acquisition, approaches to diagnosis and management, and common strategies for the prevention of infection.
细菌和真菌感染是重症监护病房（ICU）患者的常见问题。大型跨国现患率调查发现，高达50%的ICU患者在任何时候都被诊断出患有细菌或真菌感染。ICU中的感染有其自身的挑战。致病微生物往往具有内在和获得性耐药机制，这使得经验性和针对性抗菌药物的选择具有挑战性。ICU中的感染与患者更差的临床结局相关。我们综述了ICU中细菌和真菌感染的流行病学。我们讨论了感染获得的危险因素、诊断和管理方法以及预防感染的常见策略。
