Rossi Gemma, Petrone Maria Chiara, Healey Andrew J, Arcidiacono Paolo Giorgio
Pancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute IRCCS, Vita Salute San Raffaele University, 20132 Milan, Italy.
Department of Clinical Surgery, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UK.
Diagnostics (Basel). 2023 Apr 27;13(9):1561. doi: 10.3390/diagnostics13091561.
In recent years, small pancreatic neuroendocrine tumors (pNETs) have shown a dramatic increase in terms of incidence and prevalence, and endoscopic ultrasound (EUS) radiofrequency ablation (RFA) is one potential method to treat the disease in selected patients. As well as the heterogeneity of pNET histology, the studies reported in the literature on EUS-RFA procedures for pNETs are heterogeneous in terms of ablation settings (particularly ablation powers), radiological controls, and radiological indications. The aim of this review is to report the current reported experience in EUS-RFA of small pNETs to help formulate the procedure indications and ablation settings. Another aim is to evaluate the timing and the modality of the radiological surveillance after the ablation. Moreover, new studies on large-scale series are needed in terms of the safety and long-term oncological efficacy of RFA on these small lesions.
近年来，小胰腺神经内分泌肿瘤（pNETs）的发病率和患病率显著上升，内镜超声（EUS）射频消融（RFA）是治疗部分选定患者该疾病的一种潜在方法。除了pNET组织学的异质性外，文献中报道的关于pNETs的EUS-RFA手术在消融设置（特别是消融功率）、放射学对照和放射学指征方面也存在异质性。本综述的目的是报告目前已报道的小pNETs的EUS-RFA经验，以帮助制定手术指征和消融设置。另一个目的是评估消融后放射学监测的时机和方式。此外，就RFA对这些小病变的安全性和长期肿瘤学疗效而言，还需要开展大规模系列的新研究。
